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ATF3 — TNF

Pathways - manually collected, often from reviews:

• OpenBEL Selventa BEL large corpus: ATF3 → TNF (increases) Kawauchi et al., J Biol Chem 2002*
  Evidence: Treatment with TNF-alpha caused rapid induction of ATF3 in HUVECs and prevented the decrease of cell viability.

Text-mined interactions from Literome

Valladares et al., Endocrinology 2000 : In addition, TNFalpha induced activating transcription factor-1 phosphorylation is extensively decreased by SB203580
Inoue et al., Genes Cells 2004 : TNFalpha induced ATF3 expression is bidirectionally regulated by the JNK and ERK pathways in vascular endothelial cells ... In human umbilical vein endothelial cells, the expression of constitutively active MKK7 ( MAPK kinase 7 ) increased the number of ATF3 positive cells, and dominant negative MKK7 suppressed the TNFalpha induced expression of ATF3 , indicating a requirement for the JNK pathway ... In contrast, the expression of constitutively active or dominant negative MEK1/2 ( MAPK/ERK kinase 1/2 ) suppressed or enhanced TNFalpha mediated induction of ATF3 , respectively ... In support of this, the MEK1/2 specific inhibitor U0126 enhanced the expression of ATF3 induced by TNFalpha ... Our results suggest that TNFalpha induced ATF3 gene expression is bidirectionally regulated by the JNK and ERK pathways in vascular endothelial cells
Suganami et al., Circ Res 2009 (Inflammation...) : Importantly, ATF3 , when induced by saturated fatty acids, can transcriptionally repress tumor necrosis factor-alpha production in macrophages in vitro