Gene interactions and pathways from curated databases and text-mining

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DCN — TNF

Protein-Protein interactions - manually collected from original source literature:

Studies that report less than 10 interactions are marked with *

Text-mined interactions from Literome

Al Haj Zen et al., Matrix Biol 2003 : In the present study, we investigated the effects of decorin on the production of metalloproteinases ( MMP-1, -2, -3, -9 and -13 ), tissue inhibitors of metalloproteinases ( TIMP-1, -2 ) and cytokines ( TGF-beta, IL-1beta, IL-4 and TNF-alpha )
Adam et al., Int J Androl 2012 : Furthermore, studies with human testicular peritubular cells isolated from fibrotic testis indicated that TNF-a significantly increased DCN production
Bocian et al., J Biol Chem 2013 (Disease Models, Animal...) : Compared with TNF-a , IFN-? treatment induced significantly more CXCL-10, and both factors increased synthesis of CXCL-10 in the presence of decorin
Mauviel et al., J Biol Chem 1996 : We have previously described a tumor necrosis factor alpha (TNF-alpha) response element, located between residues -188 and -140 of the human decorin promoter, that mediates the inhibitory effect of TNF-alpha on decorin gene expression ( Mauviel, A., Santra, M., Chen, Y.-Q., Uitto, J., and Iozzo, R. V. ( 1995 ) J. Biol. Chem. 270, 11692-11700 )