Challacombe et al., J Immunol 2006
(Necrosis...) :
Both in vitro and in mice, PEP005 induced MIP-2/IL-8, TNF-alpha , and IL-1beta, all mediators of neutrophil recruitment and activation
Cao et al., Inflammation 2009
(Inflammation) :
Pep 3 ( LRENECVS ) which was derived from the hydrophilic region of A1 module in CRD4 remarkably inhibited the binding of TNF-alpha to TNF-R1, and also reversed TNF-alpha induced degradation of IkappaB-alpha and nuclear translocation of NF-kappaB p65 subunit in HeLa cells
Spalinger et al., PloS one 2013
:
Loss of PTPN22 enhanced mRNA levels and secretion of interleukin (IL)-6, IL-8 and TNF in THP-1 cells and PTPN22 knockout BMDC