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TLR2 — TLR5
Text-mined interactions from Literome
Oshikawa et al., Biochem Biophys Res Commun 2003
(Lung Diseases) :
The results demonstrated three patterns of gene expression : the
TLR2 and myeloid differentiation factor 88 ( MyD88 ) gene expressions were
induced in AM in response to lipopolysaccharide (LPS), interleukin (IL)-1beta, or tumor necrosis factor-alpha or in the lung tissue of an LPS induced acute lung injury model ; the gene expressions of TLR1, -3, -6, CD14, and MD2 were unchanged ; and the TLR4 and
TLR5 gene expressions were downregulated in AM following inflammatory stimuli
Cabral et al., J Infect Dis 2006
:
Borrelia burgdorferi lipoprotein mediated
TLR2 stimulation
causes the down-regulation of
TLR5 in human monocytes
Wu et al., Int J Immunogenet 2008
:
As an important member of TLRs,
TLR1 is
involved in the recognition of triacylated lipoproteins and mycobacterial products by binding to
TLR2 to form a heterodimer
Aravalli et al., Journal of neuroinflammation 2008
(Histoplasmosis) :
Furthermore, Yps3p induced
TLR2 signaling was
suppressed by vaccinia virus encoded
TLR inhibitors
Regueiro et al., Infect Immun 2009
:
We showed that Klebsiella induced
TLR2 and TLR4 upregulation was
dependent on
TLR activation
Deng et al., Circ Res 2009
(Disease Models, Animal...) :
However, the architecture of the evolving inflammation is ligand-specific
; TLR4 ligands
cause transmural panarteritis and
TLR5 ligands promote adventitial perivasculitis
So et al., Glia 2009
(Cardiovirus Infections) :
More importantly,
TLR3 was
required for TMEV induced early
TLR2 upregulation in primary astrocytes leading to the production of TLR2 dependent cytokines such as IL-6
Chamorro et al., J Immunol 2009
:
TLR triggering on tolerogenic dendritic cells
results in
TLR2 up-regulation and a reduced proinflammatory immune program
Messlik et al., J Proteome Res 2009
(Chronic Disease...) :
The aim of this study was to characterize the
role of
TLR2 or TLR4 deficiency in epithelial cell stress responses under noninflamed and inflamed conditions using TLR-deficient mice and
TLR ( -/- ) cross bred IL-10-deficient mice as a model for genetically driven experimental colitis
Stridh et al., Journal of neuroinflammation 2011
(Hypoxia-Ischemia, Brain) :
In contrast,
TLR-2 was constitutively expressed in the brain and
TLR-2 deficiency
reduced HI injury
Charavaryamath et al., Gut microbes 2011
:
Finally,
Toll-like receptor (TLR)-4 expression was decreased but
TLR-5 and -6 expression
increased in ileal segments
Kim et al., FEMS Microbiol Lett 2012
(Inflammation) :
L. plantarum genomic DNA mediated inhibition of signaling pathway and tumor necrosis factor-alpha was accompanied by the suppression of
toll-like receptor (TLR) 2 , TLR4, and TLR9 and the induction of interleukin-1 receptor associated kinase M, a negative
regulator of
TLR
Jia et al., Shanghai Kou Qiang Yi Xue 2011
:
CD14,
TLR4 receptors are involved in P.e-LPS effect and CD14,
TLR2 and TLR4 receptors are
involved in P.g-LPS effect in mouse osteoblast
Kumar et al., PloS one 2012
(Infection...) :
Moreover, stimulation of the Muller glia with
TLR 2 , 3, 4, 5, 7 and 9 agonists
resulted in an increased
TLR expression as assayed by Western blot and flow cytometry
Deng et al., Immunol Cell Biol 2013
:
The
TLR signals that regulate the phagocytic ability of macrophages were also
induced by TLR4 and
TLR5 activation
Wang et al., PloS one 2012
(Cell Transformation, Neoplastic...) :
TLR2 : TLR6 complexes
mediate the effect of NF-?B inactivation by CDA-2
Feriotti et al., PloS one 2013
(Disease Susceptibility...) :
Mannan or P. brasiliensis
induced decreased expression of MR and
TLR2 on A/J macrophages, whereas CR3,
TLR4 and TLR2 were reduced on B10.A cells