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HLA-G — MYLIP
Text-mined interactions from Literome
Zhu et al., Am J Obstet Gynecol 2010
:
The
effect of the overexpressed
miR-152 on
HLA-G expression, trophoblast invasion, and natural killer ( NK ) cell mediated cytolysis were assessed by reverse-transcription polymerase chain reaction ( RT-PCR ) and Western blot analysis, transwell invasion assay, and NK cell cytotoxicity assay, respectively ... The
miR-152 repressed
HLA-G expression but exerted no effect on JEG-3 cell invasion, and overexpression of miR-152 led to increased NK cell mediated cytolysis in JEG-3 cells
Manaster et al., PloS one 2012
:
Here we demonstrate that
miR-148a and miR-152 down-regulate HLA-G expression by binding its 3'UTR and that this down-regulation of
HLA-G affects LILRB1 recognition and consequently, abolishes the LILRB1 mediated inhibition of NK cell killing