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PRKAB1 — SETD2
Text-mined interactions from Literome
Lee et al., J Biol Chem 2003
(Prostatic Neoplasms) :
In the present study, we considered a role of AMPK in the adaptive response to hypoxia by examining whether
AMPK is
involved in the regulation of
hypoxia-inducible factor-1 (HIF-1) , a heterodimeric transcription factor that is critical for hypoxic induction of physiologically important genes ... Under these conditions, blockade of AMPK activity by a pharmacological or molecular approach significantly attenuated hypoxia induced responses such as HIF-1 target gene expression, secretion of vascular endothelial growth factor, glucose uptake, and HIF-1 dependent reporter gene expression, indicating that
AMPK is
critical for the
HIF-1 transcriptional activity and its target gene expression ... Its functional requirement for HIF-1 activity was also demonstrated in several different cancer cell lines, but
AMPK activation alone was not
sufficient to stimulate the
HIF-1 transcriptional activity
Emerling et al., FEBS Lett 2007
:
Our results show that
AMPK is not
required for the hypoxic activation of
HIF-1 ... Interestingly, the
AMPK inhibitor, Compound C,
inhibits the hypoxic activation of
HIF-1 independent of AMPK
Bohensky et al., Pediatr Nephrol 2010
:
Chondrocyte autophagy is stimulated by
HIF-1 dependent
AMPK activation and mTOR suppression ... In addition, we showed that thapsigargin treatment activated
AMPK and autophagy in a
HIF-1 dependent manner ... Based on these findings, it is concluded that because of the micro-environmental changes experienced by the chondrocyte, autophagy is activated by
AMPK in a
HIF-1 dependent manner