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CHUK — IL8

Text-mined interactions from Literome

Li et al., J Exp Med 1999 : Accordingly, IKKbeta-deficient cells are defective in activation of IKK and NF-kappaB in response to either tumor necrosis factor alpha or interleukin 1
Wang et al., Infect Immun 2001 : These data indicate that micrococci and PGN induce TLR2 dependent activation of the gene for IL-8 and that this activation requires MyD88, IRAK, NIK, IKK , and NF-kappaB and may also utilize TRAF6 and, to a lesser extent, TRAF2
Casola et al., Virology 2002 : Interleukin-8 gene regulation in intestinal epithelial cells infected with rotavirus : role of viral induced IkappaB kinase activation ... Rotavirus infection of HT-29 induced IkappaB kinase (IKK) activation and overexpression of a dominant negative mutant of IKK-beta greatly reduced rotavirus induced IL-8 promoter activation and NF-kappaB-driven transcription, indicating that IKK is involved in rotavirus induced IL-8 gene expression and NF-kappaB activation
Catley et al., Br J Pharmacol 2005 (Asthma) : Similarly, IKK beta ( KA ) and I kappa B alpha delta N overexpression also inhibited IL-1beta- and TNF alpha dependent increases in ICAM-1, IL-8 and GM-CSF in addition to IL-1beta mediated increases in cyclooxygenase-2 expression, whereas IKK alpha ( KM ) overexpression had little effect on these outputs
Catley et al., Mol Pharmacol 2006 (Pulmonary Disease, Chronic Obstructive) : As observed above, ICAM-1, IL-6, IL-8 , GM-CSF, RANTES, MCP-1, GROalpha, NAP-2, and ENA-78 expression was reduced by the IKK inhibitors
Lamothe et al., J Biol Chem 2007 : Reconstituting TRAF6-deficent cells with various TRAF6 mutants, we clearly demonstrate the requirement for the TRAF6 RING domain and site-specific auto-ubiquitination of TRAF6 to activate IKK in response to interleukin-1
Grund et al., Mol Pharmacol 2008 (Endometriosis...) : Interestingly, MEK, p38, and IKK inhibitors block TNF-alpha induced IL-8 , IL-6, and GM-CSF secretion and 12z invasion, whereas the PI3K inhibitors do not
Rasmussen et al., Inflamm Res 2008 (Inflammation) : An IkappaB kinase 2 inhibitor, sc514, also strongly reduced IL-8 and significantly induced p53 protein levels
Du et al., J Interferon Cytokine Res 2012 (Glioma) : IKK inhibitors inhibit glioma cell proliferation, as well as TNF induced RelA ( p65 ) nuclear translocation and NF?B dependent IL8 gene expression
O'Connell et al., J Biol Chem 1998 : Recently, we have reported that the tumor necrosis factor and interleukin 1 signaling pathways activate two kinases, IKK1 and IKK2 ... Recently, we have reported that the tumor necrosis factor and interleukin 1 signaling pathways activate two kinases, IKK1 and IKK2