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FGFR1 — SRC
Pathways - manually collected, often from reviews:
Protein-Protein interactions - manually collected from original source literature:
Studies that report less than 10 interactions are marked with *
Text-mined interactions from Literome
Jin et al., J Immunol 2002
:
In contrast,
Src kinase activity was not
involved in class I-mediated transfer of
FGFR from cytoplasmic stores to the cell surface
Kilkenny et al., J Biol Chem 2003
:
To address the
role of
c-Src in
FGFR1 signaling, we compared proliferative responses of murine embryonic fibroblasts (MEF) deficient in c-Src, Yes, and Fyn to MEF expressing either endogenous levels or overexpressing c-Src
Li et al., J Cell Sci 2004
:
FRS2 dependent
SRC activation is
required for
fibroblast growth factor receptor induced phosphorylation of Sprouty and suppression of ERK activity ... Activation of
SRC via fibroblast growth factor signalling is
dependent upon FRS2 and
fibroblast growth factor receptor kinase activity
Chen et al., J Biol Chem 2009
:
Furthermore, we show that PDGF-BB induces tyrosine phosphorylation of
FGFR1 and that this phosphorylation is
mediated by PDGF receptor-beta ( PDGFRbeta ), but not
c-Src
Dudka et al., Cancer Res 2010
:
Tyrosine phosphorylation of STAT3 was also dependent on concomitant
FGFR dependent activity of
SRC and JAK kinases
Auciello et al., J Cell Sci 2013
:
However,
FGFR activation
stimulates clathrin mediated endocytosis ; FGF treatment increases the number of CCPs, including those undergoing endocytosis, and this effect is mediated by
Src and its phosphorylation target Eps8