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PKD1 — SRC
Protein-Protein interactions - manually collected from original source literature:
Studies that report less than 10 interactions are marked with *
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MIPS CORUM Polycystin-1 multiprotein complex (ACTN1, CDH1, SRC, JUP, VCL, CTNNB1, PXN, BCAR1, PKD1, PTK2, TLN1):
Polycystin-1 multiprotein complex (ACTN1, CDH1, SRC, JUP, VCL, CTNNB1, PXN, BCAR1, PKD1, PTK2, TLN1) complex (ACTN1-BCAR1-CDH1-CTNNB1-JUP-PKD1-PTK2-PXN-SRC-TLN1-VCL)
Geng et al., Biochim Biophys Acta 2000
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IRef Corum Interaction:
Complex of 12 proteins
(association, cosedimentation through density gradient)
Geng et al., Biochim Biophys Acta 2000
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IRef Hprd Interaction:
SRC
—
PKD1
(in vivo)
Geng et al., Biochim Biophys Acta 2000
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IRef Hprd Interaction:
SRC
—
PKD1
(in vitro)
Geng et al., Biochim Biophys Acta 2000
-
IRef Ophid Interaction:
PKD1
—
SRC
(aggregation, interologs mapping)
Brown et al., Bioinformatics 2005
Text-mined interactions from Literome
Waldron et al., J Biol Chem 2000
:
Genistein, or the specific
Src inhibitors PP-1 and PP-2 ( 1-10 micrometer )
inhibited H ( 2 ) O ( 2 ) -mediated
PKD activation by 45 %, indicating that Src contributes to this signaling pathway
De Kimpe et al., Cell Signal 2009
:
Src , a well-known cortactin kinase, strongly
potentiated the in vivo
PKD mediated cortactin phosphorylation ... This Src effect is neither mediated by pre-phosphorylation of cortactin nor by
activation of
PKD by
Src
Arun et al., Oncogene 2011
:
Thus, our data indicate that UVB irradiation of keratinocytes induces
Src mediated activation of
PKD , which protects cells from UVB stimulated apoptosis, providing a possible explanation for the observed upregulation of PKD in BCC