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NA — PLD5
Text-mined interactions from Literome
Parinandi et al., Antioxid Redox Signal 1999
:
Furthermore,
NAC blocked diamide- or BSO mediated changes in GSH levels,
PLD activity, and protein tyrosine phosphorylation
Nakamura et al., J Leukoc Biol 1998
:
N-acetyl-L-cysteine (NAC) , which is known as a multipotential agent ; an antioxidant, a thiol reagent, or a tyrosine kinase inhibitor,
inhibited N-formyl-methionyl-leucyl-phenylalanine ( fMLP ) -induced
phospholipase D ( PLD ) activation in HL60 cells in a concentration dependent manner ( IC50 = 2 mM ) ... These results suggest that
NAC inhibits fMLP induced
PLD activation through blockage of protein tyrosine phosphorylation, which is located at the downstream of PI-3 kinase