Gene interactions and pathways from curated databases and text-mining

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CCL2 — ROCK2

Text-mined interactions from Literome

Shimada et al., FEBS Lett 2010 : In summary, MCP-1 production was partly regulated by ROCK acting upstream of p38 and JNK and mediated downstream by NF-kappaB
Le Dréau et al., Glia 2010 : Using a panel of kinase inhibitors, we demonstrated that NOV action on CCL2 and CXCL1 production involved a Rho/ROCK/JNK/NF-kappaB and a Rho/qROCK/p38/NF-kappaB pathway, respectively
Rafferty et al., Cell Immunol 2012 : Suppressing ROCK with the Y27632 inhibitor suppressed IL-1 stimulated Caco-2 cell CXCL8/IL-8 and IEC-6 cell CCL2/MCP-1 secretion and mRNA levels