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EGFR — MUC17
Text-mined interactions from Literome
Shim et al., Am J Physiol Lung Cell Mol Physiol 2001
(Metaplasia) :
These findings indicate that
EGFR signaling is
involved in IL-13 induced
mucin production
Takeyama et al., Am J Respir Crit Care Med 2001
(Asthma) :
These findings suggest a sequence of events by which
EGFR activation is
involved in
mucin expression in asthmatic airway epithelium
Nadel et al., Respir Res 2001
(Asthma...) :
Role of
epidermal growth factor receptor activation in regulating
mucin synthesis
Gray et al., Mol Pharmacol 2004
:
However, neither inhibition of
epidermal growth factor receptor (EGFR) activation with the tyrosine kinase inhibitor 4- ( 3-chloroanilino ) -6,7-dimethoxyquinazoline HCl ( AG-1478 ) or EGFR blocking antibody nor inhibition of extracellular signal regulated kinase/P-38 mitogen activated protein kinases with specific inhibitors
blocked IL-1beta stimulation of MUC5AC
mucin production
Mao et al., Zhonghua Jie He He Hu Xi Za Zhi 2004
(Pulmonary Disease, Chronic Obstructive) :
It is suggested that
EGFR activation is
involved in
mucin expression in COPD airways
Burgel et al., Thorax 2004
:
Roles of
epidermal growth factor receptor activation in epithelial cell repair and
mucin production in airway epithelium
Slomiany et al., Inflammopharmacology 2004
:
Using [ ( 3 ) H ] glucosamine labeled mucous acinar cells of sublingual salivary gland in culture, we show that stimulatory effect of beta-adrenergic agonist, isoproterenol, on
mucin secretion was
inhibited in a concentration dependent manner by
EGFR kinase inhibitor, PD153035, as well as wortmannin, an inhibitor of PI3K
Deshmukh et al., Am J Respir Crit Care Med 2005
:
Metalloproteinases
mediate mucin 5AC expression by
epidermal growth factor receptor activation
Piludu et al., Eur J Morphol 2003
:
Since this pattern of labelling must be related to the internalisation process of the ligand-GFR complex, our results support the hypothesis that
EGFR activation takes place in mucous cells and
affects mucin production in human salivary glands
Słomiany et al., J Physiol Pharmacol 2005
:
Using [ ( 3 ) H ] glucosamine labeled gastric mucosal cells, we show that stimulatory effect of beta-adrenergic agonist, isoproterenol, on
mucin secretion was
inhibited by
EGFR kinase inhibitor, PD153035, as well as wortmannin, a specific inhibitor of PI3K
Kim et al., Am J Physiol Lung Cell Mol Physiol 2005
:
In previous work, we showed that
epidermal growth factor receptor (EGFR) activation
causes mucin expression in airway epithelium in vivo and in human NCI-H292 airway epithelial cells and normal human bronchial epithelial ( NHBE ) cells in vitro ... In support of this hypothesis, in dense cultures of NCI-H292 cells and in NHBE cells at air-liquid interface, blockade of E-cadherin mediated cell-cell contacts decreased
EGFR dependent
mucin production ... E-cadherin blockade also increased EGFR dependent cell proliferation and TGF-alpha induced EGFR tyrosine phosphorylation in dense cultures of NCI-H292 cells, suggesting that E-cadherin promotes
EGFR dependent
mucin production and inhibits EGFR dependent cell proliferation via modulation of EGFR phosphotyrosine levels
Baginski et al., Am J Respir Cell Mol Biol 2006
(Carcinoma, Mucoepidermoid) :
CSE also enhanced expression and production of MUC5AC
mucin induced by
epidermal growth factor receptor (EGFR) ligands TGF-alpha and amphiregulin, as well as LPS- and TNF-alpha- induced expression and/or release of TGF-alpha and amphiregulin ... Furthermore, ( 4- [ ( 3-bromophenyl ) amino ] -6,7-diaminoquinazoline ), a potent inhibitor of
EGFR ,
blocked synergistic induction of MUC5AC
mucin
Zhen et al., Am J Respir Cell Mol Biol 2007
(Metaplasia) :
However, there was constitutive release of TGF-alpha from normal human bronchial epithelial cells, and inhibition of TGF-alpha or
EGFR reduced both constitutive and IL-13 induced
mucin production
Hegab et al., Chest 2007
(Bronchial Neoplasms...) :
Both in vivo and in vitro, the induction of MUC5AC and
mucin synthesis were
inhibited by niflumic acid, and/or a selective
EGFR tyrosine kinase inhibitor, AG-1478
Qi et al., Eur Cytokine Netw 2010
:
It is known that activation of
epidermal growth factor receptor (EGFR) and its downstream signaling cascade are
involved in
mucin production ... In this investigation, we demonstrate that NE-induced
mucin production
requires reactive oxygen species ( ROS ) production, which activates TACE, resulting in TGF-a shedding, and
EGFR phosphorylation in NCI-H292 epithelial cells
Rada et al., Mucosal Immunol 2011
(Cystic Fibrosis) :
Reactive oxygen species mediate inflammatory cytokine release and
EGFR dependent
mucin secretion in airway epithelial cells exposed to Pseudomonas pyocyanin
Karacsonyi et al., Am J Respir Cell Mol Biol 2012
:
Epidermal growth factor receptor signaling
mediates vesicant induced airway epithelial secretion of interleukin-6 and production of
mucin ... This study assessed the
role of
epidermal growth factor receptor (EGFR) signaling in mediating the effects of exposure to vesicants on the secretion of cytokines and production of
mucin in human airway epithelial cells