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EGFR — VAV1

Protein-Protein interactions - manually collected from original source literature:

Studies that report less than 10 interactions are marked with *

• IRef Biogrid Interaction: VAV1 — EGFR (direct interaction, unspecified method) Jones et al., Nature 2006
• IRef Biogrid Interaction: VAV1 — EGFR (physical association, affinity chromatography technology) Moores et al., Mol Cell Biol 2000*
• IRef Hprd Interaction: VAV1 — EGFR (in vivo) Moores et al., Mol Cell Biol 2000*
• IRef Intact Interaction: VAV1 — EGFR (direct interaction, protein array) Jones et al., Nature 2006
• IRef Ophid Interaction: VAV1 — EGFR (aggregation, interologs mapping) Brown et al., Bioinformatics 2005
• IRef Ophid Interaction: VAV1 — EGFR (aggregation, confirmational text mining) Jones et al., Nature 2006

Text-mined interactions from Literome

Palmby et al., Mol Cancer Res 2004 (Cell Transformation, Neoplastic...) : Because Vav is activated by the epidermal growth factor receptor and other tyrosine kinases involved in cancer development, defining the role of aberrant Vav signaling may identify activities of receptor tyrosine kinases important for human oncogenesis
Sarkar et al., Curr Biol 2007 : We show that germ cells signal via the Egf class ligand Spitz ( Spi ) and provide evidence that the Egfr associates with and acts through the guanine nucleotide exchange factor Vav to regulate activities of Rac1