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C1QB — IL6
Text-mined interactions from Literome
Baruah et al., J Leukoc Biol 2006
:
C1q increases the phagocytosis of apoptotic cells by DC and the release of
interleukin-12 in the presence of TLR4 ligands and apoptotic cells ; PTX3 inhibits both events
Fraser et al., J Neurochem 2010
(Blister) :
Microglia added to C1q coated wells or fed apoptotic neurons or neuronal blebs coated with C1q suppressed the lipopolysaccharide induced production of proinflammatory cytokines interleukin (IL)-1alpha, IL-1beta,
IL-6 and TNF-alpha, while the presence of
C1q enhanced levels of the chemokine MCP-1/CCL2
Bottazzi et al., J Biol Chem 1997
:
The capacity to bind
C1q , mediated by the pentraxin domain, is consistent with the view that PTX3, produced in tissues by endothelial cells or macrophages in
response to
interleukin-1 and tumor necrosis factor, may act as a local regulator of innate immunity