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NGF — PI3

Text-mined interactions from Literome

Kelly et al., Neuropharmacology 2000 : The evidence presented is consistent with the hypothesis that PI 3-kinase activation , possibly by NGF , plays a role in expression of LTP in dentate gyrus
Bilderback et al., J Neurochem 2001 : Intriguingly, NGF induced an association of activated PI 3-kinase with acid sphingomyelinase (SMase) ... NGF stimulated PI 3-kinase activity was necessary for inhibition of acid SMase but was not required for ligand induced association of the p85 subunit of PI 3-kinase with the phospholipase
Kimpinski et al., J Neurosci Res 2001 (MAP Kinase Signaling System) : Activation of PI 3-kinase and SNT by both NGF and IGF-1 correlated with their effects on neurite growth
Kronfeld et al., Eur J Immunol 2002 : The results of this study indicate that NGF is involved in B cell survival and that this effect is mediated by PI3-kinase dependent activation of PKCzeta
Ohmichi et al., Neuron 1992 : NGF causes the rapid stimulation of PI-3 kinase activity detected in anti-phosphotyrosine, but not in anti-trk, immunoprecipitates
Wang et al., Neurotox Res 2001 : These effects of NGF required activation of both PI 3-kinase and MAP kinase signal pathways
Wu et al., Cell Signal 2005 : Here, we investigated the possible involvement of G ( i/o ) proteins in nerve growth factor (NGF) induced pro-survival phosphatidylinositol-3-kinase (PI3K)/Akt signaling in rat pheochromocytoma PC12 cells
Itakura et al., J Neurochem 2005 : These results indicate that PI3-kinase participates in the enhancement of neurotransmitter release by two distinct mechanisms : EGF and NGF activate PI3-kinase in the plasma membrane, whereas IGF-1 activates PI3-kinase possibly in the intracellular membrane, leading to enhancement of neurotransmitter release in a MAPK dependent and -independent manner respectively
Park et al., Mol Cells 2006 : The p38 mitogen activated protein kinase ( MAPK ) inhibitor, SB203580, phosphatidylinositol 3-kinase (PI-3K) inhibitor, LY294003, protein kinase A (PKA) inhibitor, H89, and protein kinase C ( PKC ) inhibitor, chelerythrine, had no effect on activation of promoter IV by NGF
Park et al., J Biol Chem 2007 : Specifically, NGF enhanced TrkA phosphorylation, PI3K activity, and Akt phosphorylation
Ohmichi et al., Biochemistry 1993 : AG879 also inhibited NGF induced PLC-gamma 1 phosphorylation, phosphatidylinositol-3 (PI3) kinase activation , the association of the tyrosine phosphorylated proteins pp100 and pp110 with the p85 subunit of PI-3 kinase, mitogen activated protein and raf-1 kinases, and c-fos induction
Spear et al., Arch Biochem Biophys 1998 : Activation of PI 3-kinase by NGF pretreatment completely protected against both the enhanced apoptosis induced by FGF-1 pretreatment and NGF posttreatment and the apoptosis induced by peroxynitrite alone