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CDH1 — SMAD7
Protein-Protein interactions - manually collected from original source literature:
Studies that report less than 10 interactions are marked with *
Text-mined interactions from Literome
Medici et al., Mol Biol Cell 2006
:
However, our results also demonstrate that a complete loss of
E-cadherin and transformation to the mesenchymal phenotype are
dependent on
Smad signaling, which subsequently stimulates formation of beta-catenin/LEF-1 complexes that induce EMT
Tang et al., J Biol Chem 2008
:
Here we show that
Smad7 promotes cell-cell adhesion by stabilizing beta-catenin and consequently
increases the
beta-catenin-E-cadherin complex level at the plasma membrane ...
Smad7 increases the stabilized beta-catenin to form a complex with E-cadherin and
stabilizes the
E-cadherin-beta-catenin complex ...
Smad7 increases the stabilized beta-catenin to form a complex with E-cadherin and
stabilizes the
E-cadherin-beta-catenin complex
Huang et al., Xi Bao Yu Fen Zi Mian Yi Xue Za Zhi 2008
:
In the Smad7 infected cells, the overexpression of
Smad7 resulted in a marked decrease of alpha-SMA protein and hydroxyproline synthesis, but a increase of
E-cadherin protein, as well as the retainment of epithelial phenotypic appearance
DiVito et al., Pigment Cell Melanoma Res 2010
(Disease Progression...) :
We propose that
Smad7 suppresses ß-catenin degradation and
promotes interaction with
N-cadherin , stabilizing association with neighboring dermal fibroblasts, thus mitigating invasion