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IGF1 — PLCG1

Text-mined interactions from Literome

Zapf-Colby et al., Oncogene 1999 : NGF, but not IGF-I , stimulates tyrosine phosphorylation and activation of PLC-gamma1 which can be inhibited in a dose dependent manner by phosphoinositide-specific phospholipase C ( PI-PLC ) inhibitor U73122 ( IC50=4 microM )
Hong et al., Biochem Biophys Res Commun 2001 : However, PI 3-kinase appeared to play a more important role than tyrosine phosphorylation in IGF-I activation of PLC-gamma1 ... Taken together, these results suggest that IGF-I regulation of muscle differentiation is dependent on the activation of PLC-gamma1 and Akt/PKB, both of which are downstream mediators of PI 3-kinase
Chattopadhyay et al., J Cell Sci 2002 (MAP Kinase Signaling System) : Lastly, the data demonstrate that insulinlike growth factor stimulated tyrosine phosphorylation of phospholipase C-gamma1 in both adherent and suspension cells