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MYC — PLAU
Pathways - manually collected, often from reviews:
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OpenBEL Selventa BEL large corpus:
MYC
→
Complex of PLAU-PLAUR
(increases, PLAU/PLAUR Activity)
Evidence: In addition to the influence on the protein kinase system, uPA can regulate gene expression. The binding of uPA to uPAR has been shown to stimulate downstream up-regulation of various transcription factors: AP1 in the HT-1080 cell line [54] and c-Jun, c-Myc, and c-fos factors in SaOS2 cells [55]. Recently, the possibility of signal transduction into the cell by the receptor systems associated with urokinase endocytosis was shown [56].
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WikiPathways Wnt Signaling Pathway and Pluripotency:
EP300
→
Complex of 11 proteins
(activation)
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WikiPathways Wnt Signaling Pathway and Pluripotency:
ZBTB33
→
Complex of 11 proteins
(mim-inhibition)
Protein-Protein interactions - manually collected from original source literature:
Studies that report less than 10 interactions are marked with *
Text-mined interactions from Literome
Hou et al., Cardiovasc Res 2007
(Anoxia) :
c-Myc is
essential for
urokinase plasminogen activator expression on hypoxia induced vascular smooth muscle cells ... The purpose of this study was to investigate whether
c-Myc regulates expression of
urokinase plasminogen activator (uPA) on hypoxia induced vascular smooth muscle cells ( VSMCs ) ... The results show that
c-Myc was
essential for hypoxia induced
uPA expression and activity, resulting in VSMC migration and invasion
Alfano et al., Mol Cell Biol 2010
:
Thus, the differential
regulation of
uPA and uPAR by
c-Myc and Ras correlates with the effects of these two oncoproteins on cell motility, invasiveness, and survival