◀ Back to CCNH

CCNH — RARA

Pathways - manually collected, often from reviews:

• NCI Pathway Database Retinoic acid receptors-mediated signaling: RAR alpha/9cRA/Cyclin H complex (RARA-CCNH-RXRA) → Rxr alpha (RXRA) (modification, collaborate) Gaillard et al., Proc Natl Acad Sci U S A 2006
  Evidence: assay, physical interaction
• NCI Pathway Database Retinoic acid receptors-mediated signaling: RAR alpha/9cRA/Cyclin H complex (RARA-CCNH-RXRA) → RAR alpha/9cRA/Cyclin H complex (RARA-CCNH) (modification, collaborate)
  Gaillard et al., Proc Natl Acad Sci U S A 2006
  Evidence: assay, physical interaction
• NCI Pathway Database Retinoic acid receptors-mediated signaling: Rxr alpha (RXRA) → RAR alpha/9cRA/Cyclin H complex (RARA-CCNH) (modification, collaborate)
  Gaillard et al., Proc Natl Acad Sci U S A 2006
  Evidence: assay, physical interaction
• NCI Pathway Database Retinoic acid receptors-mediated signaling: RAR alpha (RARA) → TFIIH complex (CDK7-MNAT1-CCNH) (modification, collaborate)
  Keriel et al., Cell 2002*, Bour et al., Proc Natl Acad Sci U S A 2005*, Gaillard et al., Proc Natl Acad Sci U S A 2006, Rochette-Egly et al., Cell 1997*
  Evidence: mutant phenotype, assay, physical interaction, other species
• NCI Pathway Database Retinoic acid receptors-mediated signaling: TFIIH complex (CDK7-MNAT1-CCNH) → RAR alpha/9cRA complex (RARA) (modification, activates)
  Keriel et al., Cell 2002*, Bour et al., Proc Natl Acad Sci U S A 2005*, Gaillard et al., Proc Natl Acad Sci U S A 2006, Rochette-Egly et al., Cell 1997*
  Evidence: mutant phenotype, assay, physical interaction, other species
• NCI Pathway Database Retinoic acid receptors-mediated signaling: Cyclin H (CCNH) → RAR alpha/9cRA complex (RARA) (modification, collaborate)
  Bour et al., Proc Natl Acad Sci U S A 2005*, Gaillard et al., Proc Natl Acad Sci U S A 2006
  Evidence: mutant phenotype, assay, physical interaction
• NCI Pathway Database Retinoic acid receptors-mediated signaling: Cyclin H (CCNH) → RAR alpha/9cRA/Cyclin H complex (RARA-CCNH) (modification, collaborate)
  Bour et al., Proc Natl Acad Sci U S A 2005*, Gaillard et al., Proc Natl Acad Sci U S A 2006
  Evidence: mutant phenotype, assay, physical interaction
• NCI Pathway Database Retinoic acid receptors-mediated signaling: TFIIH complex (CDK7-MNAT1-CCNH) → RAR alpha/9cRA complex (RARA) (modification, activates)
  Bour et al., Proc Natl Acad Sci U S A 2005*, Gaillard et al., Proc Natl Acad Sci U S A 2006
  Evidence: mutant phenotype, assay, physical interaction
• NCI Pathway Database Retinoic acid receptors-mediated signaling: TFIIH complex (CDK7-MNAT1-CCNH) → RAR alpha/9cRA/Cyclin H complex (RARA-CCNH) (modification, activates)
  Bour et al., Proc Natl Acad Sci U S A 2005*, Gaillard et al., Proc Natl Acad Sci U S A 2006
  Evidence: mutant phenotype, assay, physical interaction
• NCI Pathway Database Retinoic acid receptors-mediated signaling: RAR alpha/9cRA complex (RARA) → RAR alpha/9cRA/Cyclin H complex (RARA-CCNH) (modification, collaborate)
  Bour et al., Proc Natl Acad Sci U S A 2005*, Gaillard et al., Proc Natl Acad Sci U S A 2006
  Evidence: mutant phenotype, assay, physical interaction

Text-mined interactions from Literome

Brondani et al., Biochem Biophys Res Commun 2005 : The transcription factor TFIIH mediates phosphorylation of the retinoic acid receptor alpha (RARalpha) at position Ser77
Bruck et al., EMBO J 2009 : We demonstrate that MSK1 phosphorylates RARalpha at S369 located in the ligand binding domain, allowing the binding of TFIIH and thereby phosphorylation of the N-terminal domain at S77 by cdk7/cyclin H ... Finally, the phosphorylation cascade initiated by MSK1 controls the recruitment of RARalpha/TFIIH complexes to response elements and subsequently RARalpha target gene activation