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EPO — SOCS2
Text-mined interactions from Literome
Jegalian et al., J Interferon Cytokine Res 2002
:
Using two independent approaches, one involving inhibition of specific signaling molecules and the other employing cell lines that express particular EpoR mutants and thereby activate only subsets of signaling cascades, we demonstrate that induction of SOCS1,
SOCS2 , SOCS3, and cytokine-inducible SH2 containing protein ( CIS ) in
response to
EPO stimulation appears to depend on Stat5 but not on mitogen activated protein kinase ( MAPK ) or phosphatidylinositol 3-kinase (PI3K)
Wang et al., Neuroreport 2004
:
Our data suggest that up-regulation of
SOCS2 in neuronal progenitor cells derived from the adult SVZ may
regulate EPO enhanced neuronal differentiation
Singh et al., PloS one 2012
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For example, not only Socs3 plus
Socs2 but also Spred2, Spred1 and Eaf1 were
EPO induced as negative-feedback components