Gene interactions and pathways from curated databases and text-mining

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IL2 — NPM1

Text-mined interactions from Literome

Freed et al., Toxicol Appl Pharmacol 1991 : Both NEM and NPM suppressed IL-2 production at doses that did not affect proliferation
Zhang et al., Proc Natl Acad Sci U S A 2011 : These results demonstrate that the oncogenic tyrosine kinase NPM-ALK induces epigenetic silencing of the IL-2R? gene and that IL-2R? acts as a tumor suppressor by reciprocally inhibiting expression of NPM-ALK