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HMOX1 — PPARG

Text-mined interactions from Literome

Kitamura et al., Neurosci Lett 1999 : However, PPARgamma activator alone induced HO-1 expression and further enhanced LPS/IFN-gamma induced HO-1 expression ... These results suggest that activation of PPARgamma negatively regulate iNOS expression and positively regulates HO-1 expression in glial cells
Wayman et al., FASEB J 2002 (Myocardial Infarction...) : The mechanisms of the cardioprotective effects of 15D-PGJ2 may include 1 ) activation of PPAR-alpha, 2 ) activation of PPAR-gamma , 3 ) expression of HO-1 , and 4 ) inhibition of the activation of NF-kappaB in the ischemic reperfused heart
Ptasinska et al., FASEB J 2007 : NO* mediated PPARgamma binding and NO* induction of cyclooxygenase-2 (COX-2), diacylglycerol (DAG) kinase alpha ( DGKalpha ), and heme oxygenase-1 (HO-1) , genes with well characterized PPRE motifs, were cGMP independent
Krönke et al., Arterioscler Thromb Vasc Biol 2007 : Analysis of the human HO-1 promoter in transient transfection experiments together with mutational analysis and gel shift assays revealed a direct transcriptional regulation of HO-1 by PPARalpha and PPARgamma via 2 PPAR responsive elements ... We demonstrate that HO-1 expression is transcriptionally regulated by PPARalpha and PPARgamma , indicating a mechanism of anti-inflammatory and antiproliferative action of PPAR ligands via upregulation of HO-1
Lim et al., Toxicol Appl Pharmacol 2007 : In addition, ROS scavenger pretreatment suppressed 15d-PGJ ( 2 ) -induced HO-1 expression while PPARgamma antagonist did not, suggesting nuclear translocation of Nrf-2 and subsequent HO-1 expression was ROS dependent rather than PPARgamma dependent
O'Brien et al., Journal of thrombosis and haemostasis : JTH 2009 : 15d-PGJ ( 2 ) -induced HO-1 was independent of PPARgamma , but could be replicated using other electrophilic prostaglandins, suggesting that the electrophilic properties of 15d-PGJ ( 2 ) were important for HO-1 induction
Ferguson et al., Am J Physiol Lung Cell Mol Physiol 2009 : We report here that the PPARgamma ligands 15d-PGJ2 and 2-cyano-3,12-dioxoolean-1,9-dien-28-oic acid ( CDDO ), which have potent antifibrotic effects in vitro, also strongly induce HO-1 expression in primary human lung fibroblasts
Li et al., FEBS J 2010 : Taken together, our findings suggest that activation of PPARgamma induces HO-1 expression, and that this in turn stimulates p21 ( WAF1 ) expression to suppress PASMC proliferation