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INS — KL

Text-mined interactions from Literome

Kurosu et al., Science 2005 (Insulin Resistance) : Alleviation of aging-like phenotypes in Klotho-deficient mice was observed by perturbing insulin and IGF1 signaling, suggesting that Klotho mediated inhibition of insulin and IGF1 signaling contributes to its anti aging properties
Yamamoto et al., J Biol Chem 2005 : Thus, Klotho induced inhibition of insulin/IGF-1 signaling is associated with increased resistance to oxidative stress, which potentially contributes to the anti aging properties of klotho
Château et al., Aging 2010 : While membrane bound Klotho, which is primarily expressed in the kidney, acts as an obligate co-receptor of FGF23 to regulate phosphate homeostasis, secreted Klotho , resulting from the shedding of the KL1-KL2 ectodomain into the bloodstream, inhibits Insulin/IGF1 signalling
Lin et al., Endocrinology 2012 : The purpose of this study was to investigate whether Klotho plays a role in the regulation of insulin secretion in MIN6 ß-cells by overexpression and silencing of Klotho ... It is interesting that overexpression of Klotho increased glucose induced insulin secretion in MIN6 ß-cells ... This study demonstrated, for the first time, that Klotho may enhance glucose induced insulin secretion by up-regulating plasma membrane levels of TRPV2 and thus glucose induced calcium responses ... These findings reveal a previously unidentified role of Klotho in the regulation of glucose induced insulin secretion in MIN6 ß-cells