Kasibhatla et al., Curr Opin Investig Drugs 2007
(Diabetes Mellitus, Type 2) :
Mounting evidence indicates that protein tyrosine phosphatase (PTP)1B negatively regulates insulin and leptin signaling making it a prime target for enhancing insulin sensitivity and controlling body mass
Tiganis et al., FEBS J 2013
(Diabetes Mellitus, Type 2...) :
Despite their high degree of similarity, PTP1B and TCPTP act together in vitro and in vivo to regulate insulin signaling and glucose homeostasis