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INS — SMAD3

Text-mined interactions from Literome

Buenemann et al., Carcinogenesis 2001 : Of these agents, only insulin led to a significant reduction of TGFbeta stimulated Smad-reporter activity, suggesting that the other compounds interfere with TGFbeta induced apoptosis downstream of Smad mediated primary transcriptional responses at a level that may be constitutively altered in apoptosis-resistant hepatoma cell lines
Li et al., J Lipid Res 2008 : Insulin or adenovirus mediated expression of constitutively active AKT1 inhibited FoxO1 and Smad3 synergy
Watanabe et al., Biochem Biophys Res Commun 2008 : In this study, human insulin promoter was activated by Smad2, Smad3 and the pancreatic and duodenal homeobox factor-1 ( PDX-1 ) in the ALK7 pathway
Lin et al., J Biol Chem 2009 (Diabetes Mellitus, Type 2...) : Transforming growth factor-beta/Smad3 signaling regulates insulin gene transcription and pancreatic islet beta-cell function ... We identify insulin as a TGF-beta target gene and show that the TGF-beta signaling effector Smad3 occupies the insulin gene promoter and represses insulin gene transcription ... Transduction of adenoviral Smad3 into primary human and non-human primate islets suppresses insulin content, whereas, dominant negative Smad3 enhances insulin levels