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CTNNB1 — ERBB2

Pathways - manually collected, often from reviews:

• OpenBEL Selventa BEL large corpus: Complex of CTNNB1-ERBB2 → ERBB2 (directlyIncreases, CTNNB1/ERBB2 Activity)
  Evidence: To investigate the potential interaction of Tiam1, HER2, and beta -catenin, cell lysates were immunoprecipitated with an anti-HER2 antibody, and the precipitated material was immunoblotted with different antibodies. We found no evidence of an association of Tiam1 with HER2 receptors (Fig. 2B). In contrast, there was a significant increase in the content of beta -catenin associated with activated HER2 receptor (Fig. 2B).
• BioCarta trefoil factors initiate mucosal healing: TFFs/ErbB1/ERBB2 complex (EGFR-ERBB2-TFF3_TFF2_TFF1) → beta-catenin (CTNNB1) (modification, activates)
• KEGG Adherens junction: EGFR/ERBB2 → CTNNB1 (protein-protein, inhibition)

Protein-Protein interactions - manually collected from original source literature:

Studies that report less than 10 interactions are marked with *

• IRef Biogrid Interaction: CTNNB1 — ERBB2 (physical association, affinity chromatography technology) Bonvini et al., Cancer Res 2001*
• IRef Biogrid Interaction: CTNNB1 — ERBB2 (physical association, affinity chromatography technology) Schroeder et al., J Biol Chem 2002*
• IRef Biogrid Interaction: CTNNB1 — ERBB2 (colocalization, imaging technique) Schroeder et al., J Biol Chem 2002*
• IRef Biogrid Interaction: CTNNB1 — ERBB2 (direct interaction, far western blotting) Kanai et al., Biochem Biophys Res Commun 1995*
• IRef Biogrid Interaction: CTNNB1 — ERBB2 (direct interaction, pull down) Kanai et al., Biochem Biophys Res Commun 1995*
• IRef Hprd Interaction: CTNNB1 — ERBB2 (in vitro) Bonvini et al., Cancer Res 2001*, Kanai et al., Biochem Biophys Res Commun 1995*
• IRef Hprd Interaction: CTNNB1 — ERBB2 (in vivo) Bonvini et al., Cancer Res 2001*, Kanai et al., Biochem Biophys Res Commun 1995*
• IRef Innatedb Interaction: ERBB2 — CTNNB1 (unknown, -) Bonvini et al., Cancer Res 2001*
• IRef Innatedb Interaction: ERBB2 — CTNNB1 (unknown, -) Ochiai et al., Biochem Biophys Res Commun 1994*
• IRef Intact Interaction: Complex of 59 proteins (association, tandem affinity purification) Li et al., Molecular systems biology 2013
• IRef Ophid Interaction: ERBB2 — CTNNB1 (aggregation, interologs mapping) Brown et al., Bioinformatics 2005

Text-mined interactions from Literome

Bourguignon et al., J Biol Chem 2007 (Ovarian Neoplasms) : Because HA-induced beta-catenin phosphorylation, nuclear translocation, and TCF/LEF transcriptional activation is effectively blocked by the ErbB2 inhibitor, AG825, we conclude that HA/CD44-N-WASP associated ErbB2 activation is required for beta-catenin mediated signaling events
Liu et al., Int J Cancer 2009 (Carcinoma, Hepatocellular...) : Given that HBxAg constitutively activates beta-catenin and that upregulated ErbB-2 promotes beta-catenin signaling in other tumor types, experiments were designed to ask whether HBxAg was associated with upregulated expression of ErbB-2 ... Treatment of HepG2X cells with ErbB-2 specific siRNA not only reduced ErbB-2 expression, but also reduced the expression of beta-catenin, suggesting that ErbB-2 contributed to the stabilization of beta-catenin