Lau et al., Oncogene 2011
(Ovarian Neoplasms) :
In this study, we showed that loss of E-cadherin induced ovarian cancer cell growth and constitutive activation of phosphoinositide 3-kinase (PI3K)/Akt signaling by the inhibition of phosphatase and tensin homolog (PTEN) transcription through the downregulation of early growth response gene 1 (Egr1) Hannafon et al., Breast Cancer Res 2011
(Breast Neoplasms...) :
Knockdown of the putative oncogenic miRNA miR-182 and miR-183, both highly overexpressed in DCIS, increased the expression of chromobox homolog 7 (CBX7) ( which regulates E-cadherin expression ), DOK4, NMT2 and EGR1 Cheng et al., Oncogene 2013
(Ovarian Neoplasms) :
Egr-1 mediates epidermal growth factor induced downregulation of E-cadherin expression via Slug in human ovarian cancer cells