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IGF1 — SLC2A3

Text-mined interactions from Literome

Copland et al., Biochim Biophys Acta 2007 : IGF-1 controls GLUT3 expression in muscle via the transcriptional factor Sp1 ... Insulin-like growth factor-1 (IGF-1) increased endogenous Glut3 protein in cultured L6 myotubes, and similarly stimulated luciferase activity in a construct of the human GLUT3 5'-UTR linked to a luciferase reporter gene
Dimitriadis et al., Eur J Endocrinol 2008 (Hyperthyroidism) : In monocytes from the euthyroid subjects, IGF-I increased the abundance of GLUT3 and GLUT4 on the monocyte surface by 25 and 21 % respectively ( P < 0.0005 with repeated measures ANOVA )
Yu et al., Brain Res 2012 : IGF-1 induces hypoxia-inducible factor 1a-mediated GLUT3 expression through PI3K/Akt/mTOR dependent pathways in PC12 cells ... So, we hypothesized that HIF-1a might play important role in the process of IGF-1 induced GLUT3 ... Using echinomycin, a HIF-1 inhibitor, and HIF-1a siRNA, we demonstrated IGF-1 induced GLUT3 expression through HIF-1a in neuronal PC12 cells ... Moreover, IGF-1 stimulated HIF-1a and GLUT3 protein expression through phosphatidylinositol 3-kinase (PI3K)/Akt/mTOR dependent pathways ... In conclusion, we showed that the expression of GLUT3 in response to IGF-1 was dependent on PI-3-kinase and mTOR activity, and required the transcription factor HIF-1a