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PLAT — TNF
Text-mined interactions from Literome
Chia et al., Arterioscler Thromb Vasc Biol 2003
(Vasculitis) :
Intra-arterial
tumor necrosis factor-alpha impairs endothelium dependent vasodilatation and
stimulates local
tissue plasminogen activator release in humans
Gingras et al., Biochem Biophys Res Commun 2004
:
RT-PCR analysis and gene reporter assays using the human tPA promoter indicated that upregulation of the tPA gene transcription by both Neovastat and
TNFalpha was correlated with the phosphorylation of JNK1/2 and of IkappaB and that SP600125 and BAY11-7082, inhibitors of JNK and IkappaK, respectively,
inhibit the increase of
tPA gene transcription induced by Neovastat and TNFalpha
Aderka et al., Isr J Med Sci 1991
(Disseminated Intravascular Coagulation...) :
At the endothelial level
TNF down-regulates thrombomodulin ( thus preventing protein C formation ) and
inhibits the production of
tissue plasminogen activator (t-PA) , thus impairing anticoagulant mechanisms
Haile et al., J Cereb Blood Flow Metab 2012
(Hypoxia-Ischemia, Brain) :
We present in vitro and in vivo evidence indicating that endogenous
tPA and recombinant tPA
induce the expression of neuronal
tumor necrosis factor-a
Pineda et al., Glia 2012
(MAP Kinase Signaling System) :
Here, we found that
tPA is
required for Aß-mediated microglial inflammatory response and
tumor necrosis factor-a release
Trân-Thang et al., Br J Cancer 1996
(Colonic Neoplasms) :
Tumour necrosis factor alpha (TNF-alpha) and interleukin-1 beta (IL-1 beta)
increased in several, but not all, cell lines the production of urokinase-type plasminogen activator ( uPA ),
tissue-type PA (tPA) and plasminogen activator inhibitor type 1 ( PAI-1 ) as analysed by zymography, enzyme immunoassays and Northern analysis