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HSP90AA1 — IRF6

Text-mined interactions from Literome

Hsu et al., Mol Pharmacol 2007 : In essence, GA decreased LPS induced Hsp90/pp60Src heterocomplex formation
Barabutis et al., Am J Physiol Lung Cell Mol Physiol 2013 : LPS induces pp60c-src mediated tyrosine phosphorylation of Hsp90 in lung vascular endothelial cells and mouse lung ... LPS induced Hsp90 phosphorylation was prevented by the Hsp90 inhibitor 17-allyl-amino-demethoxy-geldanamycin ( 17-AAG ) in vitro as well as in lungs from LPS treated mice, in vivo ... LPS induced Hsp90 phosphorylation was also prevented by the pp60 ( src ) inhibitor PP2 ... Additionally, Hsp90 phosphorylation was induced by infecting cells with a constitutively active pp60 ( src ) adenovirus, whereas either a dominant negative pp60 ( src ) adenovirus or reduced expression of pp60 ( src ) by a specific siRNA prevented the LPS induced Y phosphorylation of Hsp90 ... Transfection of HLMVEC with the nonphosphorylatable Hsp90ß Y300F mutant prevented LPS induced Hsp90ß tyrosine phosphorylation but not pp60 ( src ) activation