Hankinson et al., Mol Interv 2009
(Chloracne) :
Sutter and coworkers recently reported that epidermal growth factor (EGF) represses the dioxin mediated induction of CYP1A1 in cultured normal human keratinocytes by inhibiting the recruitment of the transcriptional coactivator protein p300 to the CYP1A1 gene
Kohn et al., Toxicol Appl Pharmacol 1993
:
The model successfully reproduced the observed tissue distribution of TCDD, the concentrations of CYP1A1 and CYP1A2, and the effects of TCDD on the Ah, estrogen, and EGF receptors over a wide dose range