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IFNG — XIAP

Text-mined interactions from Literome

Kim et al., Biochem Biophys Res Commun 2005 (Insulinoma...) : Here, we found that : ( i ) XIAP level was inversely correlated with tumor necrosis factor (TNF)-alpha induced apoptosis in MIN6N8 insulinoma cells ; ( ii ) adenoviral XIAP overexpression abrogated the TNF-alpha induced apoptosis through inhibition of caspase activity ; ( iii ) downregulation of XIAP by antisense oligonucleotide or Smac peptide sensitized MIN6N8 cells to TNF-alpha induced apoptosis ; ( iv ) XIAP expression was induced by TNF-alpha through a nuclear factor-kappaB (NF-kappaB) dependent pathway, and interferon (IFN)-gamma prevented such an induction in a manner independent of NF-kappaB, which presents a potential mechanism underlying cytotoxic IFN-gamma/TNF-alpha synergism
Kim et al., Diabetes 2007 (Diabetes Mellitus, Type 1) : The induction of X-linked inhibitor of apoptosis protein by TNF-alpha was inhibited by IFN-gamma in STAT1 ( +/- ) islet cells but not in STAT1 ( -/- ) islet cells