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CDKN1A — STAT1
Text-mined interactions from Literome
Huang et al., J Biol Chem 2000
:
The increased expression of
p21 ( waf/cip1 ) by thrombin was p53 independent,
STAT1 dependent , and protein synthesis independent
Chen et al., Cancer Res 2000
(Muscle Neoplasms...) :
Activation of
STAT1 in response to IFN-gamma
resulted in increased
p21WAF1 expression and growth suppression in RMS cells containing unmethylated SIE-1 but failed to induce p21WAF1 or growth inhibition in RD and A673 cells, both of which were completely methylated within SIE-1
Bhunia et al., Cell 2002
(Polycystic Kidney, Autosomal Dominant) :
Mouse embryos lacking Pkd1 have defective
STAT1 phosphorylation and
p21 ( waf1 )
induction
Arany et al., Anticancer Res 2003
(Carcinoma, Squamous Cell...) :
Semiquantitative RT-PCR, Western blotting, gel-shift analysis ( EMSA ), antisense gene expression and application of a STAT1-knockout cell line demonstrated that activation of the
p21WAF1 gene was IRF-1 and
STAT1 dependent
Baran-Marszak et al., Blood 2004
:
Expression of
STAT1beta inhibited the phosphorylation, the DNA binding activity, and the transcriptional activity of STAT1alpha, as well as the expression of STAT1alpha target genes such as
p21WAF1/CIP1 , TAP1, IRF1, and PKR
Nowroozi et al., Hum Mol Genet 2005
(Thanatophoric Dysplasia) :
Silencing of
STAT1 or 3 independently or in combination
had no significant effect on ligand independent neurite outgrowth, ERK1/2 activation or
p21 ( WAF1/CIP1 ) protein levels
Xi et al., J Natl Cancer Inst 2006
(Carcinoma, Squamous Cell...) :
Overexpression of
STAT1 abrogated the growth of SCCHN cells and xenograft tumors and
increased p21 expression
Gündogdu et al., Molecular cancer 2010
:
High levels of RhoH allow the IL3 dependent activation of
STAT1 causing decreased proliferation through upregulation of
p21Cip1 and p27Kip1
Pal-Bhadra et al., BMC cancer 2012
:
The chromatin remodelling at p21WAF1 promoter
induces p21 activity, increased
STAT-1 expression and epigenetic modifications that are responsible for ultimate cell cycle arrest and apoptosis
Napione et al., Angiogenesis 2012
:
These results indicate that the angiostatic action of IL-12 stimulated lymphomononuclear cells may lie in the capability to arrest endothelial cells in G1 phase through a mechanisms mainly based on the specific up-regulation of
p21 ( Cip1/Waf1 )
induced by the combined activity of
STAT1 , PKCd and p38 MAPK
Korpelainen et al., Oncogene 1999
:
Interestingly, co-expression of the Tie-2 receptors with
STAT1 resulted in appearance of a novel,
p21 related transcript