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CDC42 — CDH1
Pathways - manually collected, often from reviews:
Protein-Protein interactions - manually collected from original source literature:
Studies that report less than 10 interactions are marked with *
Text-mined interactions from Literome
Wäsch et al., Nature 2002
:
Furthermore, Clb5 degradation was thought to be necessary for effective dephosphorylation and
activation of the APC regulatory subunit
Cdh1 ( also known as Hct1 ) and the cyclin dependent kinase inhibitor Sic1 by the phosphatase
Cdc14 , allowing mitotic kinase inactivation and mitotic exit
Honda et al., Genes Cells 2003
:
Cdc42 or Rac was not
essential for the association of nectin-1 and
E-cadherin to form AJs
Kraemer et al., Am J Physiol Cell Physiol 2007
:
We found that homophilic engagement of
E-cadherin simultaneously
activates both Rac1 and
Cdc42
Shen et al., J Biol Chem 2008
:
Cdc42 regulates
E-cadherin ubiquitination and degradation through an epidermal growth factor receptor to Src mediated pathway ... The role of Cdc42 in regulating E-cadherin ubiquitination and degradation is underscored by the fact that constitutively active
Cdc42 ( F28L ) increases the activity of EGFR and Src and significantly
enhances E-cadherin ubiquitination and lysosomal degradation ... Furthermore, we found that GTP dependent binding of Cdc42 to
E-cadherin is
critical for
Cdc42 to induce the dissolution of adherens junctions
Sakisaka et al., Methods Mol Biol 2008
:
The endocytosis of trans interacting E-cadherin was inhibited by Rac and
Cdc42 small G proteins, which were
activated by trans interacting
E-cadherin
Erasmus et al., Biol Cell 2010
:
Cdc42 can be
activated by
E-cadherin in a breast tumour cell line, but the requirement for Cdc42 function for new junction assembly or maintenance has been contradictory