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DAPK3 — MYO10
Text-mined interactions from Literome
Niiro et al., J Biol Chem 2001
:
These results suggest that
ZIP kinase is
responsible for Ca ( 2+ ) independent
myosin phosphorylation and contraction in smooth muscle
Komatsu et al., J Cell Biol 2004
:
The kinase responsible for the phosphorylation was ZIP kinase because ( a ) the kinase in the cell extracts phosphorylated Ser19 and Thr18 of MLC20 with similar potency ; ( b ) immunodepletion of ZIP kinase from the cell extracts markedly diminished its myosin II kinase activity ; and ( c ) disruption of
ZIP kinase expression by RNA interference
diminished myosin phosphorylation, and resulted in the defect of cell polarity and migration efficiency ... These results suggest that
ZIP kinase is
critical for
myosin phosphorylation and necessary for cell motile processes in mammalian fibroblasts