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Southall et al., J Pharmacol Exp Ther 2003
(Calcium Signaling) :
Activation of the epidermal VR1 by capsaicin also resulted in an increased release of interleukin-8 and prostaglandin E2, and the stimulated release was attenuated by capsazepine
Yang et al., Exp Eye Res 2010
:
On the other hand, the TRPV1 mediated increases in IL-6 and IL-8 release are elicited through both EGFR dependent and EGFR independent signaling pathways
Pan et al., Invest Ophthalmol Vis Sci 2011
:
ELISA assessed the effect of TRPV1 activation on the release of IL-6 and IL-8 ... Hypertonic stress elicited TRPV1 channel stimulation mediates increases in a proinflammatory cytokine IL-6 and a chemoattractant IL-8 by eliciting EGFR transactivation, MAPK, and NF-?B activation
Wang et al., Molecular vision 2011
(MAP Kinase Signaling System) :
TRPV1 induced increases in IL-6/IL-8 release occur through TAK1 activation of JNK1 dependent and JNK1 independent signaling pathways