◀ Back to STAT3
CXCL12 — STAT3
Pathways - manually collected, often from reviews:
Text-mined interactions from Literome
Burger et al., Oncogene 2005
(Cell Transformation, Neoplastic...) :
In CXCR2 transfected NIH 3T3 cells and human microvascular endothelial cells ( HMEC ), which express the CXCR2 constitutively,
STAT3 is phosphorylated upon
stimulation with IL-8 (
CXCL8 )
Lee et al., Int J Oncol 2009
(Adenocarcinoma...) :
SDF-1alpha induced rapid phosphorylation of Erk1/2 MAPK but did not
promote phosphorylation of
Stat3 or Akt
Gao et al., Stem Cells 2009
:
Impaired MSC migration correlated with decreased levels of phosphorylated STAT3 and ERK1/2, suggesting that
SDF-1 stimulation
activates Jak2/STAT3 as well as MEK/ERK1/2 signaling, which in turn promotes migration of MSCs toward tumor cells
Pfeiffer et al., Br J Cancer 2009
(Lung Neoplasms...) :
Small cell lung cancer cell lines present constitutive phosphorylation of
STAT3 , and in the reference cell lines NCI-H69 and NCI-H82 constitutive phosphorylation was further
increased by
CXCL12 stimulation
Kim et al., Cancer research and treatment : official journal of Korean Cancer Association 2008
:
SDF-1 induced the phosphorylation of AKT and ERK1/2 in the PLC/PRF5 cells and the phosphorylation of
Stat3 , AKT and ERK1/2 in the Hep3B cells
Kanda et al., Endocrinology 2011
(Psoriasis) :
This indicates the involvement of NF-?B in CXCL8, CXCL10, and CCL20 induction by visfatin and the
involvement of
STAT3 in
CXCL8 induction
Huang et al., Am J Physiol Heart Circ Physiol 2011
(Myocardial Reperfusion Injury) :
SDF-1 binding to its cognate receptor CXCR4 has been shown to
activate STAT3 in a variety of cells
Pini et al., J Leukoc Biol 2012
(Inflammation...) :
However, the delayed resolution of neutrophil infiltration ; sustained production of CXCL1,
CXCL2 , and CCL2 ; prolonged
activation of
STAT-3 ; and induction of MMP-7 in the pancreas, as well as heightened induction of serum amylase A of DIO mice, were blunted significantly in DIO IL-6 KO mice
Shen et al., Tumour Biol 2013
(Neoplasm Invasiveness...) :
CXCR4 knockdown in bladder cancer T24 cells impaired
CXCL12 induced cell invasion and
Stat3 activation