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BMP2 — PI3
Text-mined interactions from Literome
Ghosh-Choudhury et al., J Biol Chem 2003
:
BMP-2 increased
PI 3-kinase activity in these cells in a time dependent manner, resulting in increased expression of sarcomeric myosin heavy chain ( MHC ) and MEF-2A ...
BMP-2 also increased transcription of a reporter gene driven by an MEF-2-specific DNA element in a
PI 3-kinase dependent manner ... Together these data provide the first evidence that
BMP-2 induced
PI 3-kinase signaling regulates MEF-2A expression and define a mechanism of MEF-2A dependent BMP-2 transcription
Ghosh-Choudhury et al., FEBS Lett 2003
:
Ly294002, a pharmacological inhibitor of PI 3 kinase, blocked
BMP-2 induced
PI 3 kinase activity completely ... Also we provide the first evidence that
BMP-2 induced
PI 3 kinase activity regulates this cardiomyocyte function
Sugimori et al., J Bone Miner Metab 2005
:
We investigated the involvement of
phosphatidylinositol 3-kinase (PI3K)/Akt mediated NF-kappaB activation by
BMP-2 stimulation in the modulation of this antiapoptotic process in a chondrocytic cell line, N1511
Gamell et al., J Cell Sci 2008
:
BMP2 induction of actin cytoskeleton reorganization and cell migration
requires PI3-kinase and Cdc42 activity
Graham et al., Cancer Sci 2010
(Neoplasm Metastasis...) :
We recently reported that
phosphoinositide 3-kinase (PI3K)/protein kinase B ( Akt )
mediates transcriptional regulation and activation of
bone morphogenetic protein (BMP)-2 signaling by nuclear factor (NF)-kappaB in bone metastatic prostate cancer cells
Liu et al., Biochem Biophys Res Commun 2013
:
Furthermore, in the presence of exogenous
BMP-2 ,
PI3K and Akt inhibitors
blocked Runx2 and osteocalcin expression, although BMP-2 did not activate Akt
Ghosh-Choudhury et al., J Biol Chem 2013
:
Remarkably, inhibition of c-Abl significantly suppressed
BMP-2 stimulated
PI 3-kinase activity and its downstream Akt phosphorylation