◀ Back to CREB1
CREB1 — CREBBP
Pathways - manually collected, often from reviews:
-
OpenBEL Selventa BEL large corpus:
CREB1
→
Complex of CREB1-CREBBP
(directlyIncreases, CREB1/CREBBP Activity)
Evidence: Moreover, PP1 was shown to act as a major CTD phosphatase in nuclear extracts and to affinity-purify with RNA polymerase II. Both PP1 and the nuclear regulator NIPP1 have also been identified as components of the Tat-associated RNA polymerase II complex, which regulates transcription from the human immunodeficiency virus type 1 promoter (40, 275). The transcription factor CREB mediates the expression of cAMP-induced genes by binding to a conserved cAMP-responsive element. Phosphorylation of CREB...
-
BioCarta transcription regulation by methyltransferase of carm1:
CBP/p300/CREB complex (CREBBP-CREB1-EP300)
→
BCL-2 (BCL2)
(transcription, activates)
-
BioCarta inhibition of huntingtons disease neurodegeneration by histone deacetylase inhibitors:
histone transacetylase (CREBBP)
→
CREB (CREB1)
(modification, collaborate)
-
BioCarta inhibition of huntingtons disease neurodegeneration by histone deacetylase inhibitors:
histone transacetylase (CREBBP)
→
CBP/CREB/CREB complex (CREBBP-CREB1)
(modification, collaborate)
-
BioCarta inhibition of huntingtons disease neurodegeneration by histone deacetylase inhibitors:
CREB (CREB1)
→
CBP/CREB/CREB complex (CREBBP-CREB1)
(modification, collaborate)
-
BioCarta transcription regulation by methyltransferase of carm1:
CBP/p300/CREB complex (CREBBP-CREB1-EP300)
→
p300/CBP complex (CREBBP-EP300)
(modification, collaborate)
-
BioCarta transcription regulation by methyltransferase of carm1:
CBP/p300/CREB complex (CREBBP-CREB1-EP300)
→
CREB (CREB1)
(modification, collaborate)
-
BioCarta transcription regulation by methyltransferase of carm1:
p300/CBP complex (CREBBP-EP300)
→
CREB (CREB1)
(modification, collaborate)
-
KEGG Melanogenesis:
PRKACA/PRKACB/PRKACG/PRKX
→
Complex of CREB1-CREB3-CREB3L1-CREB3L2-CREB3L3-CREB3L4-CREBBP-EP300
(protein-protein, activation)
-
KEGG Melanogenesis:
Complex of CREB1-CREB3-CREB3L1-CREB3L2-CREB3L3-CREB3L4-CREBBP-EP300
→
MITF
(gene expression, expression)
-
KEGG Prostate cancer:
ATF4/CREB1/CREB3/CREB3L1/CREB3L2/CREB3L3/CREB3L4/CREB5
→
CREBBP/EP300
(protein-protein, inhibition)
-
NCI Pathway Database HIF-1-alpha transcription factor network:
CREB1 (CREB1)
→
HIF1A/ARNT/Cbp/p300 complex (HIF1A-ARNT-EP300_CREBBP)
(transcription, activates)
Hu et al., Mol Cell Biol 2003, Semenza et al., J Biol Chem 1996, Ebert et al., Mol Cell Biol 1998
Evidence: mutant phenotype, assay, reporter gene, physical interaction
Protein-Protein interactions - manually collected from original source literature:
Studies that report less than 10 interactions are marked with *
-
IRef Bind Interaction:
CREB1
—
CREBBP
Screaton et al., Cell 2004*
-
IRef Bind_translation Interaction:
CREB1
—
CREBBP
(two hybrid)
Screaton et al., Cell 2004*
-
IRef Bind_translation Interaction:
CREBBP
—
CREB1
(coimmunoprecipitation)
Martin et al., Nat Immunol 2005*
-
IRef Biogrid Interaction:
CREBBP
—
CREB1
(association, x-ray crystallography)
Radhakrishnan et al., Cell 1997*
-
IRef Biogrid Interaction:
CREBBP
—
CREB1
(direct interaction, pull down)
Shimomura et al., J Biol Chem 1996*
-
IRef Biogrid Interaction:
CREBBP
—
CREB1
(direct interaction, pull down)
Radhakrishnan et al., Cell 1997*
-
IRef Biogrid Interaction:
CREBBP
—
CREB1
(direct interaction, pull down)
Zhang et al., Mol Cell Biol 2000*
-
IRef Biogrid Interaction:
CREBBP
—
CREB1
(physical association, affinity chromatography technology)
Sano et al., J Biol Chem 1998*
-
IRef Biogrid Interaction:
CREBBP
—
CREB1
(direct interaction, fluorescent resonance energy transfer)
Zor et al., J Biol Chem 2002*
-
IRef Biogrid Interaction:
CREBBP
—
CREB1
(direct interaction, pull down)
Giebler et al., Mol Cell Biol 2000*
-
IRef Biogrid Interaction:
CREBBP
—
CREB1
(direct interaction, pull down)
Ledo et al., EMBO J 2002*
-
IRef Biogrid Interaction:
CREBBP
—
CREB1
(direct interaction, pull down)
Ernst et al., Mol Cell Biol 2001*
-
IRef Biogrid Interaction:
CREBBP
—
CREB1
(physical association, affinity chromatography technology)
Best et al., Proc Natl Acad Sci U S A 2004*
-
IRef Biogrid Interaction:
CREBBP
—
CREB1
(direct interaction, pull down)
Best et al., Proc Natl Acad Sci U S A 2004*
-
IRef Biogrid Interaction:
CREBBP
—
CREB1
(physical association, affinity chromatography technology)
Chan et al., J Mol Cell Cardiol 2010*
-
IRef Biogrid Interaction:
CREBBP
—
CREB1
(association, x-ray crystallography)
Yang et al., Nature 2006
-
IRef Biogrid Interaction:
CREBBP
—
CREB1
(physical association, affinity chromatography technology)
Solomou et al., J Immunol 2001*
-
IRef Biogrid Interaction:
CREBBP
—
CREB1
(physical association, affinity chromatography technology)
Poon et al., Endocrinology 2008*
-
IRef Biogrid Interaction:
CREBBP
—
CREB1
(direct interaction, two hybrid)
Du et al., J Biol Chem 1998*
-
IRef Biogrid Interaction:
CREBBP
—
CREB1
(direct interaction, two hybrid)
Kim et al., J Mol Endocrinol 2005*
-
IRef Biogrid Interaction:
CREBBP
—
CREB1
(physical association, affinity chromatography technology)
Shi et al., Proc Natl Acad Sci U S A 2004*
-
IRef Biogrid Interaction:
CREBBP
—
CREB1
(direct interaction, pull down)
Sano et al., J Biol Chem 1998*
-
IRef Hprd Interaction:
CREB1
—
CREBBP
(in vivo)
Shi et al., Proc Natl Acad Sci U S A 2004*, Radhakrishnan et al., Cell 1997*
-
IRef Hprd Interaction:
CREB1
—
CREBBP
(in vitro)
Shi et al., Proc Natl Acad Sci U S A 2004*, Radhakrishnan et al., Cell 1997*
-
IRef Intact Interaction:
CREB1
—
CREBBP
(physical association, pull down)
Ravnskjaer et al., EMBO J 2007*
-
IRef Intact Interaction:
CREB1
—
CREBBP
(physical association, anti tag coimmunoprecipitation)
Wang et al., Cancer Cell 2010*
-
IRef Intact Interaction:
Complex of CREB1-CREBBP-MEIS1
(association, anti tag coimmunoprecipitation)
Wang et al., Cancer Cell 2010*
-
IRef Ophid Interaction:
CREB1
—
CREBBP
(aggregation, interologs mapping)
Brown et al., Bioinformatics 2005
Text-mined interactions from Literome
Dal Peraro et al., Eur Biophys J 2001
:
Cyclic AMP response element binding protein (
CREB ) is
involved in activation of transcriptional DNA machinery by binding to the coactivator
CREB binding protein (CBP)
Konesky et al., J Virol 2006
:
Binding of Tax and
CREB to the vCREs
promotes association of
p300/CBP into the complex and leads to transcriptional activation
Yun et al., Mol Endocrinol 2012
:
OT also increased cAMP response element binding (
CREB)/CREB binding protein ( CBP ) expression in the nucleus and
induced the formation of
CREB1/NF-?B/CBP complexes, which was blocked by the NF-?B-specific small interfering RNA, NF-?B inhibitors, SN50, and bay11-7082
Suire et al., Eur J Biochem 1996
:
Since we observed important dissociation kinetics, we hypothesized that the binding of
CREB to the PRII site is
stabilized by
CREB binding protein (CBP) or by chicken-ovalbumin-upstream-promoter transcription factor ( COUP-TF ) binding to PRI site near to PRII