Klausen et al., Oncogene 2000
:
Inhibition of MEK activation completely abrogated OSM and IL-6 induced p27kip1 accumulation, while expression of dominant negative STAT5 decreased the OSM and IL-6 mediated inhibition of DNA-synthesis and partially inhibited p27kip1 accumulation
Motomura et al., Int J Cancer 2004
(Carcinoma, Hepatocellular...) :
The growth inhibition was mediated by p27 ( Kip1 ) accumulation, which is induced by both inhibition of ubiquitylation of p27 ( Kip1 ) and reduction of degradation activity of p27Kip1 by proteasome
Appleman et al., Cell cycle (Georgetown, Tex.) 2006
:
Downregulation of cyclin dependent kinase inhibitor p27 ( kip1 ) is critical in this process and is mediated by ubiquitin targeted degradation of p27 ( kip1 )