◀ Back to VDR
RXRA — VDR
Pathways - manually collected, often from reviews:
-
OpenBEL Selventa BEL large corpus:
VDR
→
Complex of RXRA-VDR
(directlyIncreases, RXRA/VDR Activity)
Evidence: Expression of the platelet-derived growth factor-A subunit (PDGF-A) is regulated to a significant degree by DNA elements located in the 5'-distal region of the gene. A potent basal enhancer (ACE66) Electrophoretic mobility shift assays confirmed that the ACE66 sequence was recognized as a high affinity target for binding of heterodimers of recombinant vitamin D receptor (VDR) and its partner, retinoid-X receptor-alpha (RXRalpha)
-
BioCarta control of gene expression by vitamin d receptor:
NCOA62/TSC2/TRAP220 complex (SKIIP-TSC2-PPARBP)
→
RXR/VDR/WSTF/WINAC complex (RXRA-VDR-BAZ1B-SMARCE1-SMARCC2-SMARCC1-SMARCD1-ARID1A-SMARCA4-ACTL6A-TOP2B-CHAF1A-SUPT16H)
(transcription, activates)
-
NCI Pathway Database RXR and RAR heterodimerization with other nuclear receptor:
RARs/VDR/DNA/Vit D3 complex (RARA_RARG_RARB_RARB_RARB_RARG_RARB_RARA-VDR)
→
RXRs (RXRB/RXRG/RXRB/RXRA)
(modification, collaborate)
Kahlen et al., Biochem Biophys Res Commun 1994, Cheskis et al., Mol Cell Biol 1994, Schräder et al., J Biol Chem 1993
Evidence: assay
-
NCI Pathway Database RXR and RAR heterodimerization with other nuclear receptor:
RARs/VDR/DNA/Vit D3 complex (RARA_RARG_RARB_RARB_RARB_RARG_RARB_RARA-VDR)
→
RXRs/VDR/DNA/Vit D3 complex (RXRB_RXRG_RXRB_RXRA-VDR)
(modification, collaborate)
Kahlen et al., Biochem Biophys Res Commun 1994, Cheskis et al., Mol Cell Biol 1994, Schräder et al., J Biol Chem 1993
Evidence: assay
-
NCI Pathway Database RXR and RAR heterodimerization with other nuclear receptor:
VDR/VDR/Vit D3 complex (VDR)
→
RXRs (RXRB/RXRG/RXRB/RXRA)
(modification, collaborate)
Kahlen et al., Biochem Biophys Res Commun 1994, Cheskis et al., Mol Cell Biol 1994, Schräder et al., J Biol Chem 1993
Evidence: assay
-
NCI Pathway Database RXR and RAR heterodimerization with other nuclear receptor:
VDR/VDR/Vit D3 complex (VDR)
→
RXRs/VDR/DNA/Vit D3 complex (RXRB_RXRG_RXRB_RXRA-VDR)
(modification, collaborate)
Kahlen et al., Biochem Biophys Res Commun 1994, Cheskis et al., Mol Cell Biol 1994, Schräder et al., J Biol Chem 1993
Evidence: assay
-
NCI Pathway Database RXR and RAR heterodimerization with other nuclear receptor:
None
→
RXRs/VDR/DNA/Vit D3 complex (RXRB_RXRG_RXRB_RXRA-VDR)
(modification, collaborate)
Kahlen et al., Biochem Biophys Res Commun 1994, Cheskis et al., Mol Cell Biol 1994, Schräder et al., J Biol Chem 1993
Evidence: assay
-
NCI Pathway Database RXR and RAR heterodimerization with other nuclear receptor:
RXRs (RXRB/RXRG/RXRB/RXRA)
→
VDR/VDR/DNA complex (VDR)
(modification, collaborate)
Kahlen et al., Biochem Biophys Res Commun 1994, Cheskis et al., Mol Cell Biol 1994, Schräder et al., J Biol Chem 1993
Evidence: assay
-
NCI Pathway Database RXR and RAR heterodimerization with other nuclear receptor:
RXRs (RXRB/RXRG/RXRB/RXRA)
→
RXRs/VDR/DNA/Vit D3 complex (RXRB_RXRG_RXRB_RXRA-VDR)
(modification, collaborate)
Kahlen et al., Biochem Biophys Res Commun 1994, Cheskis et al., Mol Cell Biol 1994, Schräder et al., J Biol Chem 1993
Evidence: assay
-
NCI Pathway Database RXR and RAR heterodimerization with other nuclear receptor:
RARs (RARA/RARG/RARB/RARB/RARB/RARG/RARB/RARA)
→
RXRs/VDR/DNA/Vit D3 complex (RXRB_RXRG_RXRB_RXRA-VDR)
(modification, collaborate)
Kahlen et al., Biochem Biophys Res Commun 1994, Cheskis et al., Mol Cell Biol 1994, Schräder et al., J Biol Chem 1993
Evidence: assay
-
NCI Pathway Database RXR and RAR heterodimerization with other nuclear receptor:
VDR/VDR/DNA complex (VDR)
→
RXRs/VDR/DNA/Vit D3 complex (RXRB_RXRG_RXRB_RXRA-VDR)
(modification, collaborate)
Kahlen et al., Biochem Biophys Res Commun 1994, Cheskis et al., Mol Cell Biol 1994, Schräder et al., J Biol Chem 1993
Evidence: assay
-
NCI Pathway Database Retinoic acid receptors-mediated signaling:
None
→
RXRs/VDR/DNA/Vit D3 complex (RXRB_RXRG_RXRB_RXRA-VDR)
(modification, collaborate)
Cheskis et al., Mol Cell Biol 1994
Evidence: assay
-
NCI Pathway Database Retinoic acid receptors-mediated signaling:
RXRs (RXRB/RXRG/RXRB/RXRA)
→
VDR/VDR/DNA complex (VDR)
(modification, collaborate)
Cheskis et al., Mol Cell Biol 1994
Evidence: assay
-
NCI Pathway Database Retinoic acid receptors-mediated signaling:
RXRs (RXRB/RXRG/RXRB/RXRA)
→
VDR/VDR/Vit D3 complex (VDR)
(modification, collaborate)
Cheskis et al., Mol Cell Biol 1994
Evidence: assay
-
NCI Pathway Database Retinoic acid receptors-mediated signaling:
RXRs (RXRB/RXRG/RXRB/RXRA)
→
RXRs/VDR/DNA/Vit D3 complex (RXRB_RXRG_RXRB_RXRA-VDR)
(modification, collaborate)
Cheskis et al., Mol Cell Biol 1994
Evidence: assay
-
NCI Pathway Database Retinoic acid receptors-mediated signaling:
VDR/VDR/DNA complex (VDR)
→
RXRs/VDR/DNA/Vit D3 complex (RXRB_RXRG_RXRB_RXRA-VDR)
(modification, collaborate)
Cheskis et al., Mol Cell Biol 1994
Evidence: assay
-
NCI Pathway Database Retinoic acid receptors-mediated signaling:
VDR/VDR/Vit D3 complex (VDR)
→
RXRs/VDR/DNA/Vit D3 complex (RXRB_RXRG_RXRB_RXRA-VDR)
(modification, collaborate)
Cheskis et al., Mol Cell Biol 1994
Evidence: assay
-
NCI Pathway Database Retinoic acid receptors-mediated signaling:
VDR/Vit D3/DNA complex (VDR)
→
RXRs/RXRs/DNA/9cRA complex (RXRB_RXRG_RXRB_RXRA)
(modification, collaborate)
Cheskis et al., Mol Cell Biol 1994
Evidence: assay
-
NCI Pathway Database Retinoic acid receptors-mediated signaling:
VDR/Vit D3/DNA complex (VDR)
→
RXRs/VDR/DNA/Vit D3 complex (RXRB_RXRG_RXRB_RXRA-VDR)
(modification, collaborate)
Cheskis et al., Mol Cell Biol 1994
Evidence: assay
-
NCI Pathway Database Retinoic acid receptors-mediated signaling:
RXRs/RXRs/DNA/9cRA complex (RXRB_RXRG_RXRB_RXRA)
→
RXRs/VDR/DNA/Vit D3 complex (RXRB_RXRG_RXRB_RXRA-VDR)
(modification, collaborate)
Cheskis et al., Mol Cell Biol 1994
Evidence: assay
-
NCI Pathway Database Retinoic acid receptors-mediated signaling:
None
→
RXRs/VDR/DNA/Vit D3 complex (RXRB_RXRG_RXRB_RXRA-VDR)
(modification, collaborate)
Cheskis et al., Mol Cell Biol 1994
Evidence: assay
-
NCI Pathway Database RXR and RAR heterodimerization with other nuclear receptor:
VDR/Vit D3/DNA complex (VDR)
→
RXRs/RXRs/DNA/9cRA complex (RXRB_RXRG_RXRB_RXRA)
(modification, collaborate)
Cheskis et al., Mol Cell Biol 1994
Evidence: assay
-
NCI Pathway Database RXR and RAR heterodimerization with other nuclear receptor:
VDR/Vit D3/DNA complex (VDR)
→
RXRs/VDR/DNA/Vit D3 complex (RXRB_RXRG_RXRB_RXRA-VDR)
(modification, collaborate)
Cheskis et al., Mol Cell Biol 1994
Evidence: assay
-
NCI Pathway Database RXR and RAR heterodimerization with other nuclear receptor:
RXRs/RXRs/DNA/9cRA complex (RXRB_RXRG_RXRB_RXRA)
→
RXRs/VDR/DNA/Vit D3 complex (RXRB_RXRG_RXRB_RXRA-VDR)
(modification, collaborate)
Cheskis et al., Mol Cell Biol 1994
Evidence: assay
-
NCI Pathway Database RXR and RAR heterodimerization with other nuclear receptor:
None
→
RXRs/VDR/DNA/Vit D3 complex (RXRB_RXRG_RXRB_RXRA-VDR)
(modification, collaborate)
Cheskis et al., Mol Cell Biol 1994
Evidence: assay
Protein-Protein interactions - manually collected from original source literature:
Studies that report less than 10 interactions are marked with *
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IRef Bind Interaction:
VDR
—
RXRA
Pedigo et al., Oncogene 2005*
-
IRef Bind_translation Interaction:
VDR
—
RXRA
(footprinting)
Pedigo et al., Oncogene 2005*
-
IRef Bind_translation Interaction:
VDR
—
RXRA
(electrophoretic mobility shift assay)
Pedigo et al., Oncogene 2005*
-
IRef Bind_translation Interaction:
VDR
—
RXRA
(two hybrid)
Albers et al., Mol Cell Proteomics 2005
-
IRef Biogrid Interaction:
VDR
—
RXRA
(direct interaction, pull down)
Jiménez-Lara et al., J Biol Chem 1999*
-
IRef Biogrid Interaction:
VDR
—
RXRA
(direct interaction, pull down)
Pedigo et al., Oncogene 2005*
-
IRef Biogrid Interaction:
VDR
—
RXRA
(direct interaction, pull down)
Herdick et al., J Mol Biol 2000*
-
IRef Biogrid Interaction:
VDR
—
RXRA
(colocalization, imaging technique)
Seuter et al., Biochim Biophys Acta 2007*
-
IRef Biogrid Interaction:
VDR
—
RXRA
(direct interaction, pull down)
Seuter et al., Biochim Biophys Acta 2007*
-
IRef Biogrid Interaction:
VDR
—
RXRA
(direct interaction, pull down)
Hsieh et al., J Biol Chem 2003*
-
IRef Biogrid Interaction:
VDR
—
RXRA
(direct interaction, pull down)
Sorg et al., Biochim Biophys Acta 2006*
-
IRef Biogrid Interaction:
VDR
—
RXRA
(direct interaction, two hybrid)
Wang et al., Molecular systems biology 2011
-
IRef Biogrid Interaction:
VDR
—
RXRA
(direct interaction, pull down)
Zhang et al., J Biol Chem 2001*
-
IRef Biogrid Interaction:
VDR
—
RXRA
(direct interaction, two hybrid)
Baudino et al., J Biol Chem 1998*
-
IRef Biogrid Interaction:
VDR
—
RXRA
(direct interaction, pull down)
Baudino et al., J Biol Chem 1998*
-
IRef Biogrid Interaction:
VDR
—
RXRA
(physical association, affinity chromatography technology)
Song et al., Mol Endocrinol 2006*
-
IRef Biogrid Interaction:
VDR
—
RXRA
(direct interaction, pull down)
Rachez et al., Mol Cell Biol 2000*
-
IRef Biogrid Interaction:
VDR
—
RXRA
(direct interaction, pull down)
Liu et al., Mol Endocrinol 2000*
-
IRef Biogrid Interaction:
VDR
—
RXRA
(colocalization, imaging technique)
Kim et al., J Bone Miner Res 2005*
-
IRef Biogrid Interaction:
VDR
—
RXRA
(colocalization, imaging technique)
Dunlop et al., J Mol Biol 2005*
-
IRef Biogrid Interaction:
VDR
—
RXRA
(direct interaction, pull down)
Ting et al., Endocrine 2005*
-
IRef Biogrid Interaction:
VDR
—
RXRA
(direct interaction, pull down)
Solomon et al., J Bone Miner Res 2001*
-
IRef Biogrid Interaction:
VDR
—
RXRA
(direct interaction, pull down)
Carvallo et al., J Cell Physiol 2008*
-
IRef Biogrid Interaction:
VDR
—
RXRA
(direct interaction, two hybrid)
Yanagisawa et al., Science 1999
-
IRef Biogrid Interaction:
VDR
—
RXRA
(direct interaction, pull down)
Ismail et al., Mol Endocrinol 2004*
-
IRef Biogrid Interaction:
VDR
—
RXRA
(direct interaction, pull down)
Yanagisawa et al., Science 1999
-
IRef Biogrid Interaction:
VDR
—
RXRA
(direct interaction, two hybrid)
Albers et al., Mol Cell Proteomics 2005
-
IRef Biogrid Interaction:
VDR
—
RXRA
(direct interaction, pull down)
Peleg et al., J Cell Biochem 2010*
-
IRef Dip Interaction:
Complex of VDR-VDR-RXRA-RXRA-MED1-MED1
(physical association, cosedimentation in solution)
Rochel et al., Nature structural & molecular biology 2011*
-
IRef Dip Interaction:
Complex of VDR-VDR-RXRA-RXRA-NCOA1-NCOA1
(physical association, molecular sieving)
Rochel et al., Nature structural & molecular biology 2011*
-
IRef Dip Interaction:
VDR
—
RXRA
(direct interaction, molecular sieving)
Rochel et al., Nature structural & molecular biology 2011*
-
IRef Dip Interaction:
VDR
—
RXRA
(direct interaction, pull down)
Rochel et al., Nature structural & molecular biology 2011*
-
IRef Dip Interaction:
VDR
—
RXRA
(direct interaction, cosedimentation in solution)
Rochel et al., Nature structural & molecular biology 2011*
-
IRef Dip Interaction:
VDR
—
RXRA
(direct interaction, x ray scattering)
Rochel et al., Nature structural & molecular biology 2011*
-
IRef Hprd Interaction:
Complex of 16 proteins
(in vivo)
Zhang et al., J Biol Chem 2001*
-
IRef Hprd Interaction:
Complex of RXRA-NCOA1-VDR-VDR-NCOA1-RXRA-NCOA1-VDR-RXRA
(in vivo)
Zhang et al., J Biol Chem 2001*
-
IRef Hprd Interaction:
Complex of 17 proteins
(in vivo)
Zhang et al., J Biol Chem 2001*
-
IRef Hprd Interaction:
Complex of 17 proteins
(in vivo)
Zhang et al., J Biol Chem 2001*
-
IRef Hprd Interaction:
Complex of SNW1-VDR-RXRA-VDR-RXRA-SNW1-SNW1-VDR-RXRA
(in vivo)
Zhang et al., J Biol Chem 2001*
-
IRef Hprd Interaction:
Complex of 19 proteins
(in vivo)
Koszewski et al., J Steroid Biochem Mol Biol 2003*
-
IRef Hprd Interaction:
VDR
—
RXRA
(in vitro)
Yamamoto et al., J Biol Chem 2003*, Albers et al., Mol Cell Proteomics 2005
-
IRef Hprd Interaction:
VDR
—
RXRA
(in vivo)
Yamamoto et al., J Biol Chem 2003*, Albers et al., Mol Cell Proteomics 2005
-
IRef Hprd Interaction:
VDR
—
RXRA
(two hybrid)
Yamamoto et al., J Biol Chem 2003*, Albers et al., Mol Cell Proteomics 2005
-
IRef Intact Interaction:
VDR
—
RXRA
(physical association, two hybrid)
Wang et al., Molecular systems biology 2011
-
IRef Intact Interaction:
VDR
—
RXRA
(direct interaction, electron microscopy)
Orlov et al., EMBO J 2012*
-
IRef Ophid Interaction:
VDR
—
RXRA
(aggregation, interologs mapping)
Brown et al., Bioinformatics 2005
Text-mined interactions from Literome
Segaert et al., J Invest Dermatol 2000
:
Suppression of
vitamin D receptor and
induction of
retinoid X receptor alpha expression during squamous differentiation of cultured keratinocytes ... Interferon-gamma and the phorbolester 12-O-tetradecanoyl phorbol 13-acetate, two well-known inducers of keratinocyte differentiation, both inhibited
vitamin D receptor expression but only interferon-gamma
induced retinoid X receptor alpha
Jääskeläinen et al., Eur J Biochem 1995
:
We have studied the
role of
retinoid X receptor alpha (RXR alpha) in
vitamin D receptor (VDR) responsive interactions using nuclear extracts from human osteoblast-like MG-63 osteosarcoma cells and its specific response element from human osteocalcin gene ( OC-VDRE )