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HIF1A — IRF6
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Frede et al., Biochem J 2006
(Anoxia) :
Here we report that bacterial
LPS ( lipopolysaccharide )
induces HIF-1alpha mRNA expression and
HIF-1alpha protein accumulation in human monocytes as well as in non differentiated and differentiated cells of the human monocytic cell line THP-1 under normoxic conditions ... Whereas
LPS increased
HIF-1alpha mRNA expression through activation of a NF-kappaB ( nuclear factor kappaB ) site in the promoter of the HIF-1alpha gene, hypoxia post-translationally stabilized HIF-1alpha protein ... In cells pretreated with the p44/42 MAPK inhibitor PD 98059 or with RNAi ( interfering RNA ) directed against p44/42 MAPK,
LPS induced
HIF-1alpha accumulation and ADM expression were significantly decreased
Scharte et al., J Surg Res 2006
:
LPS increases hepatic
HIF-1alpha protein and expression of the HIF-1 dependent gene aldolase A in rats
Ramanathan et al., Mol Biol Cell 2007
:
We examined whether
LPS and/or NECA
induce HIF-1alpha expression ...
HIF-1alpha is transcriptionally
induced by
LPS and post-transcriptionally up-regulated in an A2AR dependent manner
Poulaki et al., FASEB J 2007
(Leukostasis...) :
17-AAG treatment significantly suppressed the
LPS induced increase in retinal leukocyte adhesion ; vascular leakage ; NF-kappaB,
HIF-1alpha , p38, and PI-3K activity ; and VEGF, TNF-alpha, and IL-1beta levels
Kim et al., Exp Cell Res 2007
(Bacterial Infections...) :
However, the molecular mechanisms at the transcriptional level of
HIF-1alpha induction by
LPS remained undefined ... Here, we investigated the regulatory mechanism of HIF-1alpha expression by LPS in hepatocytes and identified that
LPS induced
HIF-1alpha mediate gene transcription of a typical inflammatory mediator, tumor-necrosis factor alpha (TNFalpha)
Oh et al., Neurosci Lett 2008
(Anoxia) :
We then showed that
LPS induced
HIF-1alpha mRNA expression was blocked by an antioxidant, NADPH oxidase inhibitors, and siRNA of gp91phox, a subunit of NADPH oxidase ... In addition, we showed that specific pharmacological inhibitors of PI 3-kinase and protein kinase C decreased
LPS induced
HIF-1alpha mRNA expression ... Taken together, these results suggest that
LPS induces
HIF-1alpha mRNA expression and activation via NADPH oxidase and Sp1 in BV2 microglia
Mi et al., Cell cycle (Georgetown, Tex.) 2008
:
Interestingly,
LPS did not significantly
affect HIF-1alpha protein levels or HIF-1 DNA binding activity relative to hypoxic induction ... Addition of ROS-scavengers completely abrogated the synergistic induction of HIF-1 transcriptional activity by LPS and hypoxia, but neither inhibited HIF-1 transcriptional activity induced by hypoxia alone nor affected
HIF-1alpha protein levels or HIF-1 DNA binding
induced by hypoxia alone or hypoxia plus
LPS
Ramanathan et al., J Leukoc Biol 2009
:
This switch involves transcriptional regulation of VEGF by HIF-1, transcriptional
induction of
HIF-1alpha by
LPS ( TLR4 agonist ), and A ( 2A ) R-dependent post-transcriptional regulation of HIF-1alpha stability ...
LPS induced expression of A ( 2A ) Rs and
HIF-1alpha and A ( 2A ) R-dependent HIF-1alpha mRNA and protein stabilization provide mechanisms for the synergistic effects of LPS and A ( 2A ) R agonists on macrophage VEGF expression
Nicholas et al., Immunol Cell Biol 2010
:
RNS and p38 MAP kinase ( known to contribute to
LPS induced TLR4 dependent accumulation of
HIF-1 alpha protein ) do not affect HIF-1 alpha prolyl hydroxylation
Labuzek et al., Naunyn Schmiedebergs Arch Pharmacol 2010
(Inflammation) :
The observed alterations in the release or production of inflammatory mediators may be explained by the changes in NF-kappaB,
HIF-1 alpha , and arginase I expression and 3- ( 4,5-dimethylthazol-2-yl ) -2,5-diphenyltetrazolinum bromide values in
response to
LPS , whereas the basis for the compound C effect on non stimulated microglia remains to be investigated