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CREM — FOS

Pathways - manually collected, often from reviews:

• FastForward regulation: CREM → FOS (transcriptional regulation, unknown) Kyttaris et al., J Immunol 2004*, Härtig et al., Nucleic Acids Res 1991*, Kara et al., Mol Cell Biol 1990*, Kwast-Welfeld et al., J Biol Chem 1989*, Tan et al., Mol Cell Biol 1989*
  Evidence: DNABINDING
• NCI Pathway Database Calcineurin-regulated NFAT-dependent transcription in lymphocytes: JUN/FOS/NFAT1-c-4 complex (FOS-JUN-NFATC1_NFATC2_NFATC3) → NFAT1-c-4/ICER1 complex (NFATC1_NFATC2_NFATC3-CREM) (transcription, activates)
  Bodor et al., J Biol Chem 1998
  Evidence: physical interaction
• NCI Pathway Database Calcineurin-regulated NFAT-dependent transcription in lymphocytes: NFAT1-c-4/ICER1 complex (NFATC1_NFATC2_NFATC3-CREM) → FOS (FOS) (modification, collaborate) Bodor et al., J Biol Chem 1998
  Evidence: physical interaction
• NCI Pathway Database Calcineurin-regulated NFAT-dependent transcription in lymphocytes: NFAT1-c-4/ICER1 complex (NFATC1_NFATC2_NFATC3-CREM) → JUN/FOS/NFAT1-c-4 complex (FOS-JUN-NFATC1_NFATC2_NFATC3) (modification, collaborate)
  Bodor et al., J Biol Chem 1998
  Evidence: physical interaction
• NCI Pathway Database Calcineurin-regulated NFAT-dependent transcription in lymphocytes: FOS (FOS) → ICER1 (CREM) (modification, collaborate) Bodor et al., J Biol Chem 1998
  Evidence: physical interaction
• NCI Pathway Database Calcineurin-regulated NFAT-dependent transcription in lymphocytes: JUN/FOS/NFAT1-c-4 complex (FOS-JUN-NFATC1_NFATC2_NFATC3) → ICER1 (CREM) (modification, collaborate) Bodor et al., J Biol Chem 1998
  Evidence: physical interaction
• NCI Pathway Database Calcium signaling in the CD4+ TCR pathway: NFAT1-c-4/ICER1 complex (NFATC1_NFATC2_NFATC3-CREM) → FOS (FOS) (modification, collaborate) Bodor et al., J Biol Chem 1998
  Evidence: physical interaction
• NCI Pathway Database Calcium signaling in the CD4+ TCR pathway: NFAT1-c-4/ICER1 complex (NFATC1_NFATC2_NFATC3-CREM) → JUN/FOS/NFAT1-c-4 complex (FOS-JUN-NFATC1_NFATC2_NFATC3) (modification, collaborate)
  Bodor et al., J Biol Chem 1998
  Evidence: physical interaction
• NCI Pathway Database Calcium signaling in the CD4+ TCR pathway: FOS (FOS) → ICER1 (CREM) (modification, collaborate) Bodor et al., J Biol Chem 1998
  Evidence: physical interaction
• NCI Pathway Database Calcium signaling in the CD4+ TCR pathway: JUN/FOS/NFAT1-c-4 complex (FOS-JUN-NFATC1_NFATC2_NFATC3) → ICER1 (CREM) (modification, collaborate) Bodor et al., J Biol Chem 1998
  Evidence: physical interaction
• NCI Pathway Database Calcium signaling in the CD4+ TCR pathway: JUN/FOS/NFAT1-c-4 complex (FOS-JUN-NFATC1_NFATC2_NFATC3) → NFAT1-c-4/ICER1 complex (NFATC1_NFATC2_NFATC3-CREM) (transcription, activates)
  Jain et al., J Immunol 1992, Jain et al., Nature 1993, Bodor et al., J Biol Chem 1998
  Evidence: mutant phenotype, reporter gene, physical interaction

Text-mined interactions from Literome

Masquilier et al., J Biol Chem 1992 : We also show that c-Fos does not affect the inhibitory function of CREM on c-Jun and that the transcriptional activation elicited by the other members of the jun family ( JunB, JunD, and v-Jun ) is also down-regulated by CREM
Jahng et al., Eur J Pharmacol 2004 : However, lithium induced medullary expression of c-Fos was attenuated by central L-NAME, and ICER by systemic L-NAME
Higai et al., Biochim Biophys Acta 2009 : The prolonged culture in high glucose increased inducible cAMP early repressor (ICER) II mRNA and protein levels, and overexpression of ICER II dose-dependently suppressed promoter activities of IL-2, NFAT, and AP-1