Khanal et al., Oncogene 2012
(Breast Neoplasms) :
Here, we show that peptidyl-prolyl isomerase Pin1 downregulates CDK10 protein as a result of its interaction with and ubiquitination of CDK10, thereby affecting CDK10 dependent Raf-1 phosphorylation ( S338 )
Kerkhoff et al., Mol Cell Biol 1997
(Cell Transformation, Neoplastic) :
The activation of the c-Raf-1-BxB-ER protein leads to an accumulation of high levels of cyclin D1 protein and a repression of the p27Kip1 cyclin dependent kinase inhibitor under all culture conditions tested