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PTGS2 — RUNX2

Text-mined interactions from Literome

Mehrotra et al., Biochem Biophys Res Commun 2006 : Role of Cbfa1/Runx2 in the fluid shear stress induction of COX-2 in osteoblasts ... These data suggest that transcriptional activity of Cbfa1 , independent of its level of expression, is necessary for maximal FSS induction of COX-2 in osteoblasts
Liu et al., Endocrinology 2009 : We first determined whether the suppression of Runx1 expression or activity affects Ptgs2 expression using cultured preovulatory granulosa cells isolated from immature rat ovaries primed with pregnant mare serum gonadotropin for 48 h. Knockdown of human chorionic gonadotropin induced Runx1 expression by small interfering RNA or inhibition of endogenous RUNX activities by dominant negative RUNX decreased human chorionic gonadotropin or agonist stimulated Ptgs2 expression and transcriptional activity of Ptgs2 promoter reporter constructs
Park et al., Mol Cell Endocrinol 2012 : Together, these novel findings provide support for the role of RUNX2 in down-regulation of Runx1, Ptgs2 , and Tnfaip6 during the late ovulatory period to support proper ovulation and/or luteinization