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HLA-DRA — TLR4
Text-mined interactions from Literome
Olson et al., J Immunol 2004
:
In addition,
TLR stimulation
activated up-regulation of
MHC class II and costimulatory molecules, enabling the microglia to efficiently present myelin Ags to CD4+ T cells
Lee et al., Eur J Immunol 2006
:
Comprehensive mutant analyses, electrophoretic mobility shift assays and chromatin immunoprecipitation assays, reveal that the functional interaction of NF-kappaB with the promoter element is necessary for the
TLR mediated
HLA-DRA induction by CpG-DNA and LPS
Tang et al., PloS one 2012
:
Our findings suggest that in RAW 264.7 cells ( 1 ) IFN-? provides a condition for lower concentrations of SEA to attenuate MHC class II expression ; ( 2 ) SEA attenuated IFN-? induced MHC class II expression and the IL-10 and IL-6 production is mediated at least partly by the interaction of SEA with
TLR4 ; and ( 3 ) SEA
attenuated IFN-? induced
MHC class II expression at the transcriptional level