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CPD — MYC
Text-mined interactions from Literome
Ge et al., J Hepatol 2004
(Carcinoma, Hepatocellular...) :
The aim was to investigate whether
c-Myc was
involved in
Cpd 5-induced cell growth inhibition ...
Cpd 5 was found to
inhibit c-Myc protein expression and induce c-Myc phosphorylation in Hep 3B cells ... The phosphorylation of
c-Myc was
induced by both
Cpd 5-mediated persistent extracellular signal regulated kinase ( ERK ) phosphorylation and Cpd 5 increased glycogen synthase kinase-3 ( GSK-3 ) activity ... When using GSK-3 inhibitor, SB216763, c-Myc phosphorylation was significantly decreased and c-Myc levels were restored in Cpd 5 treated cells, suggesting that
Cpd 5-mediated increase of GSK-3 activity enhanced c-Myc degradation and
resulted in reduction of
c-Myc levels ... The results suggest that
Cpd 5-mediated c-Myc phosphorylation
resulted in enhanced c-Myc protein degradation and reduced
c-Myc protein levels, which may contribute to cell growth inhibition by Cpd 5
Wang et al., J Cell Physiol 2006
(Carcinoma, Hepatocellular...) :
Furthermore,
Cpd 5
inhibited c-Myc transcriptional activity and DNA binding ability, and this inhibition was antagonized by ERK kinase ( MEK ) inhibitor U-0126, implying that the ERK pathway was involved in regulating c-Myc expression ... Since the participation of c-Myc protein in transcription requires its dimerization with Max protein, we examined the Myc-Max association in Cpd 5-treated cells and found that
Cpd 5
suppressed Myc-Max dimerization ... We found that
phospho-Myc induced by
Cpd 5 had lost its ability to bind to the c-myc promoter, whereas MEK inhibitor U-0126 antagonized this inhibitory effect