◀ Back to MYC
EP300 — MYC
Pathways - manually collected, often from reviews:
-
OpenBEL Selventa BEL large corpus:
EP300
→
MYC
(increases, MYC Activity, EP300 Activity)
Evidence: As an activator MYC recruits a number of different cofactors that possess the capability to control chromatin structure, acetylate core histones as well as transcriptional regulators, and regulate polymerase complexes (summarized in Fig. S2B) (9).
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FastForward regulation:
MYC
→
EP300
(transcriptional regulation, unknown)
Kapranov et al., Science 2002, Elias et al., Semin Dermatol 1992
Evidence: DNABINDING
-
NCI Pathway Database Validated targets of C-MYC transcriptional activation:
MYC/Max/TRRAP/GCN5/STAF65G/SPT3/TAF9/TAF10/TAF12/core Mediator complex (MYC-MAX-SUPT7L-SUPT3H-TAF9-TAF10-TAF12-TRRAP-KAT2A)
→
nucleus (EP300/CREBBP)
(transcription, activates)
Greenberg et al., Oncogene 1999, Faiola et al., Mol Cell Biol 2005, Liu et al., Mol Cell Biol 2008
Evidence: mutant phenotype, assay, reporter gene, physical interaction
-
NCI Pathway Database Validated targets of C-MYC transcriptional repression:
MIZ-1/p300 complex (ZBTB17-EP300)
→
MYC/Max/MIZ-1 complex (MYC-MAX-ZBTB17)
(modification, collaborate)
Staller et al., Nat Cell Biol 2001, Peukert et al., EMBO J 1997, Salghetti et al., EMBO J 1999
Evidence: mutant phenotype, physical interaction
-
NCI Pathway Database Validated targets of C-MYC transcriptional repression:
MIZ-1/p300 complex (ZBTB17-EP300)
→
MYC/Max complex (MYC-MAX)
(modification, collaborate)
Staller et al., Nat Cell Biol 2001, Peukert et al., EMBO J 1997, Salghetti et al., EMBO J 1999
Evidence: mutant phenotype, physical interaction
-
NCI Pathway Database Validated targets of C-MYC transcriptional repression:
p300 (EP300)
→
MYC/Max/MIZ-1 complex (MYC-MAX-ZBTB17)
(modification, collaborate)
Staller et al., Nat Cell Biol 2001, Peukert et al., EMBO J 1997, Salghetti et al., EMBO J 1999
Evidence: mutant phenotype, physical interaction
-
NCI Pathway Database Validated targets of C-MYC transcriptional repression:
p300 (EP300)
→
MYC/Max complex (MYC-MAX)
(modification, collaborate)
Staller et al., Nat Cell Biol 2001, Peukert et al., EMBO J 1997, Salghetti et al., EMBO J 1999
Evidence: mutant phenotype, physical interaction
-
NCI Pathway Database Validated targets of C-MYC transcriptional activation:
MYC/Max/TRRAP/TIP60/TIP49A/TIP49B/BAF53 complex (MYC-MAX-ACTL6A-RUVBL1-RUVBL2-TRRAP-KAT5)
→
nucleus (EP300/CREBBP)
(transcription, activates)
Greasley et al., Nucleic Acids Res 2000, Frank et al., EMBO Rep 2003, Adhikary et al., Cell 2005, Dai et al., EMBO J 2007
Evidence: mutant phenotype, reporter gene, physical interaction
-
NCI Pathway Database Validated targets of C-MYC transcriptional activation:
MYC/Max/RPL11 complex (MYC-MAX-RPL11)
→
nucleus (EP300/CREBBP)
(transcription, inhibits)
Greasley et al., Nucleic Acids Res 2000, Frank et al., EMBO Rep 2003, Adhikary et al., Cell 2005, Dai et al., EMBO J 2007
Evidence: mutant phenotype, reporter gene, physical interaction
-
NCI Pathway Database Validated targets of C-MYC transcriptional activation:
MYC/Max/TRRAP/GCN5/STAF65G/SPT3/TAF9/TAF10/TAF12/core Mediator complex (MYC-MAX-SUPT7L-SUPT3H-TAF9-TAF10-TAF12-TRRAP-KAT2A)
→
nucleus (EP300/CREBBP)
(transcription, activates)
Bouchard et al., EMBO J 1999, Bouchard et al., Genes Dev 2001, Vervoorts et al., EMBO Rep 2003
Evidence: mutant phenotype, assay, reporter gene, physical interaction
-
NCI Pathway Database Validated targets of C-MYC transcriptional activation:
MYC/Max/Cbp/p300 complex (MYC-MAX-EP300_CREBBP)
→
ODC (ODC1)
(transcription, activates)
Vervoorts et al., EMBO Rep 2003, Wagner et al., Cell Growth Differ 1993*, Bello-Fernandez et al., Proc Natl Acad Sci U S A 1993*
Evidence: mutant phenotype, assay, reporter gene, physical interaction
-
NCI Pathway Database Validated targets of C-MYC transcriptional activation:
MYC/Max/Cbp/p300 complex (MYC-MAX-EP300_CREBBP)
→
nucleus (EP300/CREBBP)
(modification, collaborate)
Vervoorts et al., EMBO Rep 2003, Adhikary et al., Cell 2005
Evidence: mutant phenotype, physical interaction
-
NCI Pathway Database Validated targets of C-MYC transcriptional activation:
MYC/Max/Cbp/p300 complex (MYC-MAX-EP300_CREBBP)
→
MYC/Max complex (MYC-MAX)
(modification, collaborate)
Vervoorts et al., EMBO Rep 2003, Adhikary et al., Cell 2005
Evidence: mutant phenotype, physical interaction
-
NCI Pathway Database Validated targets of C-MYC transcriptional activation:
nucleus (EP300/CREBBP)
→
MYC/Max complex (MYC-MAX)
(modification, collaborate)
Vervoorts et al., EMBO Rep 2003, Adhikary et al., Cell 2005
Evidence: mutant phenotype, physical interaction
-
NCI Pathway Database Validated targets of C-MYC transcriptional activation:
MYC/Max/Cbp/p300 complex (MYC-MAX-EP300_CREBBP)
→
eIF2A (EIF2S1)
(transcription, activates)
Vervoorts et al., EMBO Rep 2003, Rosenwald et al., Proc Natl Acad Sci U S A 1993*
Evidence: assay, physical interaction
-
WikiPathways Wnt Signaling Pathway and Pluripotency:
EP300
→
Complex of 11 proteins
(activation)
Protein-Protein interactions - manually collected from original source literature:
Studies that report less than 10 interactions are marked with *
-
IRef Biogrid Interaction:
EP300
—
MYC
(physical association, affinity chromatography technology)
Fujii et al., Mol Cell 2006*
-
IRef Biogrid Interaction:
EP300
—
MYC
(physical association, affinity chromatography technology)
Covic et al., EMBO J 2005*
-
IRef Biogrid Interaction:
EP300
—
MYC
(direct interaction, pull down)
Faiola et al., Mol Cell Biol 2005
-
IRef Biogrid Interaction:
EP300
—
MYC
(physical association, affinity chromatography technology)
Faiola et al., Mol Cell Biol 2005
-
IRef Biogrid Interaction:
EP300
—
MYC
(colocalization, imaging technique)
Faiola et al., Mol Cell Biol 2005
-
IRef Biogrid Interaction:
EP300
—
MYC
(direct interaction, enzymatic study)
Faiola et al., Mol Cell Biol 2005
-
IRef Biogrid Interaction:
EP300
—
MYC
(direct interaction, enzymatic study)
Zhang et al., Biochem Biophys Res Commun 2005*
-
IRef Hprd Interaction:
Complex of MYC-SNIP1-MYC-SNIP1-EP300-EP300-SNIP1-EP300-MYC
(in vivo)
Fujii et al., Mol Cell 2006*
-
IRef Hprd Interaction:
EP300
—
MYC
(in vivo)
Vervoorts et al., EMBO Rep 2003, Fujii et al., Mol Cell 2006*
-
IRef Intact Interaction:
EP300
—
MYC
(physical association, anti bait coimmunoprecipitation)
Fujii et al., Mol Cell 2006*
Text-mined interactions from Literome
Faiola et al., Mol Cell Biol 2005
:
In addition, p300 functions as a coactivator that is recruited by Myc to the promoter of the human telomerase reverse transcriptase gene, and
p300/CBP stimulates
Myc TAD dependent transcription in a HAT domain dependent manner ... Our results suggest dual
roles for
p300/CBP in
Myc regulation : as a Myc coactivator that stabilizes Myc and as an inducer of Myc instability via direct Myc acetylation
Singhal et al., Virology 2008
:
We previously showed that in quiescent cells
p300/CBP negatively regulates the cell cycle G1-S transition by keeping c-Myc in a repressed state and that adenovirus E1A
induces c-Myc by binding to p300/CBP