D'Addario et al., Gene 2006
:
Role of p38 in stress activation of Sp1 Xu et al., Cancer Res 2007
(Brain Neoplasms...) :
Enhanced DNA binding by Sp1/Sp3 requires p38-MAPK activity and correlates with increased phosphorylation of the Sp1 transcription factor
Boucher et al., Viral Immunol 2010
(HIV Infections...) :
In THP-1 cells, p38 , ERK, and JNK inhibition increased NF-kappaB and Sp1 binding to the IL-12p40 promoter, while inhibiting AP-1 binding
Lin et al., J Biol Chem 2011
:
Collectively, these data suggest that p38 dependent phosphorylation of Sp1 at Thr-453/Thr-739 is crucial for HO-1/CO induced VEGF expression in myocytes