◀ Back to CD4
CD4 — CXCR4
Pathways - manually collected, often from reviews:
-
Reactome Reaction:
CD4
→
CXCR4
(indirect_complex)
-
Reactome Reaction:
CD4
→
CXCR4
(reaction)
Wang et al., J Biol Chem 1999*, Huang et al., Science 2005*, Deng et al., Nature 1996*, Alkhatib et al., Science 1996*, Choe et al., Cell 1996*, Trkola et al., Nature 1996*, Björndal et al., J Virol 1997*, Bandres et al., J Virol 1998*, Rizzuto et al., Science 1998*, Kwong et al., Nature 1998*, Mondor et al., Virology 1998*
Protein-Protein interactions - manually collected from original source literature:
Studies that report less than 10 interactions are marked with *
Text-mined interactions from Literome
Doranz et al., J Virol 1999
:
Direct binding studies using the X4 gp120s HXB, BH8, and MN demonstrated the ability of HIV-1 gp120 to bind directly and specifically to the chemokine receptor
CXCR4 in a
CD4 dependent manner, using a conformationally complex structure on CXCR4
Lee et al., Proc Natl Acad Sci U S A 1999
(HIV Infections) :
CCR5 and
CXCR4 are the major HIV-1 coreceptors for R5 and X4 HIV-1 strains, respectively, and a threshold number of
CD4 and chemokine receptor molecules is
required to support virus infection
Mognetti et al., Clin Exp Immunol 2000
(Acquired Immunodeficiency Syndrome) :
CD4 expression was
detected in five of the 10 placentas, while membrane protein expression of CCR3,
CXCR4 and CCR5 was detected in every case, despite quantitative differences among individuals ...
CD4 expression was
detected in five of the 10 placentas, while membrane protein expression of CCR3,
CXCR4 and CCR5 was detected in every case, despite quantitative differences among individuals
Van Drenth et al., J Immunol 2000
:
Desensitization of CXC
chemokine receptor 4 ,
mediated by
IL-16/CD4 , is independent of p56lck enzymatic activity
Yi et al., Virology 2001
:
CCR5 independent fusion was not mediated by
CXCR4 and was
CD4 dependent , while CCR5 mediated fusion was partly independent of CD4
Decrion et al., J Gen Virol 2004
(HIV Infections) :
Immune activation of CD8 ( + ), but not
CD4 ( + ), T cells was
CXCR4 dependent , resulting in increased T cell apoptosis
Zerhouni et al., J Virol 2004
:
CXCR4 dependent infection of CD8+, but not
CD4+ , lymphocytes by a primary human immunodeficiency virus type 1 isolate
Wang et al., J Cell Biochem 2004
:
Constitutive association of cell surface CCR5 and
CXCR4 in the
presence of
CD4
Reed et al., Current infectious disease reports 2006
:
The targets of antiretroviral drugs include the three major HIV-1 enzymes ( reverse transcriptase, protease, and integrase ), final packaging and export of mature virions, and entry
mediated by the
CD4 receptor and the CCR5 and
CXCR4 coreceptors
Gallo et al., Retrovirology 2006
:
However, escape from inhibition by reagents that block gp120-CD4 binding,
CD4 induced
CXCR4 binding and 6-helix bundle formation, respectively, indicated large difference between HIV-1 and HIV-2 envelope glycoproteins in their CD4 induced rates of engagement with CXCR4
Takano et al., Biochim Biophys Acta 2007
:
We examined the
roles of CD4 and
CXCR4 in the adhesive interaction of
CD4+T-cells with the vascular endothelium
Lackman-Smith et al., Antimicrob Agents Chemother 2008
:
The activity is confirmed by repeat testing, and identified actives are advanced to secondary screens to determine their effect on transmission of CXCR4-tropic viruses in the
presence or absence of
CD4 and their ability to inhibit
CXCR4- and CCR5-tropic envelope mediated cell-to-cell fusion
Hood et al., Antivir Ther 2013
(HIV Infections) :
As expected, the soluble
CD4 positive control
inhibited CXCR4 ( 50 % inhibitory concentration [ IC ( 50 ) ] 3.7 µg/ml ) and CCR5 ( IC ( 50 ) 0.03 µg/ml ) tropic HIV-1 infectivity
Mondor et al., Virology 1998
:
The strength of the interaction between sgp120 and CXCR4 correlated with sgp120 affinity for the CD4-CXCR4 complex, and the interaction of sgp120MN and sgp120IIIB with
CXCR4 was highly
dependent on the level of
CD4 expressed on a variety of different T cell lines